Mussel-mimetic chitosan based injectable hydrogel with fast-crosslinking and water-resistance as tissue adhesive

被引：6

作者：

Wang, Yurui ^{[1
]}

Zhao, Jing ^{[1
]}

Wang, Xiaoran ^{[1
]}

Zhang, Rong ^{[1
]}

Liang, Fei ^{[2
]}

机构：

[1] Xian Polytech Univ, Sch Environm & Chem Engn, Xian 710048, Peoples R China

[2] Xian Med Univ, Dept Pharm, Xian 710021, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES | 2023年 / 124卷

关键词：

Catechol; Chitosan; Injectable hydrogel; Tissue adhesion; TOUGH;

D O I：

10.1016/j.ijadhadh.2023.103382

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

It is very crucial to develop ideal tissue adhesive materials with high toughness, super tissue adhesion, biode-gradability and biocompatibility for the treatment of accidental trauma and surgery. Inspired by mussels, a novel injectable bioadhesive chitosan-based hydrogel was developed by dual-ionic crosslinking in this paper, which was composed of catechol-modified chitosan (Cat-CS), thermosensitive polymer (PNAM) and NaHCO3. The gelation time of Cat-CS-PNAM/NaHCO3 hydrogel is 50 s at 37 degrees C, showing good sol-gel transition under different temperatures. The prepared hydrogels have the ability to adhere to a variety of materials surface, wherein the adhesion strength to metal surface is 126.20 +/- 15.17 kPa. They also possess compact microstructure and excellent dry/wet adhesion to tissues due to the interaction between catechol/amino groups and tissues, combined with physical crosslinking. In addition, the hydrogels can be completely degraded after 14 days in vitro and show good cytocompatibility. This newly designed mussel-inspired chitosan hydrogels have the character-istics of injectability, fast gelation, bioadhesion and biocompatibility, with great potential for application in biomedical fields.

引用

页数：10