RAF1-rearranged Spindle Cell Mesenchymal Tumor With Calcification and Heterotopic Ossification: A Case Report and Review of Literature

被引：4
作者：
Cordier, Fleur [1 ]
Loontiens, Siebe [2 ,3 ,4 ]
Van der Meulen, Joni [2 ,3 ,4 ]
Lapeire, Lore [2 ,5 ]
van Ramshorst, Gabrielle H. [6 ,7 ]
Sys, Gwen [2 ,8 ]
Van Dorpe, Jo [1 ,2 ]
Creytens, David [1 ,2 ,9 ]
机构：
[1] Univ Ghent, Ghent Univ Hosp, Dept Pathol, Ghent, Belgium
[2] Univ Ghent, Ghent Univ Hosp, Canc Res Inst Ghent, CRIG, Ghent, Belgium
[3] Univ Ghent, Mol Diagnost Ghent Univ Hosp MDG, Ghent Univ Hosp, Ghent, Belgium
[4] Univ Ghent, Dept Biomol Med, Ghent, Belgium
[5] Univ Ghent, Ghent Univ Hosp, Dept Med Oncol, Ghent, Belgium
[6] Univ Ghent, Ghent Univ Hosp, Dept Gastrointestinal Surg, Ghent, Belgium
[7] Univ Ghent, Dept Human Struct & Repair, Ghent, Belgium
[8] Univ Ghent, Ghent Univ Hosp, Dept Traumatol & Orthopaed, Ghent, Belgium
[9] Ghent Univ Hosp, Dept Pathol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2024年 / 32卷 / 01期
关键词：
spindle cell tumor; sarcoma; immunohistochemistry; next-generation sequencing; RAF1; NTRK; GENE FUSIONS; NTRK;
D O I：
10.1177/10668969231167493
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored a SLMAP::RAF1 fusion. To the best of our knowledge, this is the second case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity with this specific fusion. Remarkable is the presence of calcification and heterotopic ossification in the center of our lesion, a feature that, to our knowledge, has not been described yet in RAF1-rearranged spindle cell mesenchymal tumors.
引用
收藏
页码：133 / 139
页数：7
相关论文
共 22 条
  • [1] Spindle cell tumor with CD34 and S100 co-expression and distinctive stromal and perivascular hyalinization showing EML4-ALK fusion
    Abs, Diane
    Landman, Samuel
    Osio, Amelie
    Lepesant, Pauline
    Schneider, Pierre
    Obadia, Deborah
    Moguelet, Philippe
    Farges, Cecile
    Poirot, Brigitte
    Lehmann-Che, Jacqueline
    Lebbe, Celeste
    Battistella, Maxime
    [J]. JOURNAL OF CUTANEOUS PATHOLOGY, 2021, 48 (07) : 896 - 901
  • [2] Emerging soft tissue tumors with kinase fusions: An overview of the recent literature with an emphasis on diagnostic criteria
    Antonescu, Cristina R.
    [J]. GENES CHROMOSOMES & CANCER, 2020, 59 (08) : 437 - 444
  • [3] Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions
    Antonescu, Cristina R.
    Dickson, Brendan C.
    Swanson, David
    Zhang, Lei
    Sung, Yun-Shao
    Kao, Yu-Chien
    Chang, Wei-Chin
    Ran, Leili
    Pappo, Alberto
    Bahrami, Armita
    Chi, Ping
    Fletcher, Christopher D.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2019, 43 (10) : 1384 - 1391
  • [4] Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy
    Baranov, Esther
    Winsnes, Katrina
    O'Brien, Matthew
    Voss, Stephan D.
    Church, Alanna J.
    Janeway, Katherine A.
    DuBois, Steven G.
    Davis, Jessica L.
    Al-Ibraheemi, Alyaa
    [J]. HISTOPATHOLOGY, 2022, 81 (02) : 215 - 227
  • [5] Coffin CM., 2020, Hum PathologyCase Rep, V22, P200434
  • [6] Spinal Pleomorphic Xanthoastrocytoma With a QKI-RAF1 Fusion
    Daoud, Elena V.
    Wachsmann, Megan
    Richardson, Timothy E.
    Mella, Divya
    Pan, Edward
    Schwarzbach, Anna
    Oliver, Dwight
    Hatanpaa, Kimmo J.
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2019, 78 (01) : 10 - 14
  • [7] Mesenchymal neoplasms with NTRK and other kinase gene alterations
    Davis, Jessica L.
    Al-Ibraheemi, Alyaa
    Rudzinski, Erin R.
    Surrey, Lea F.
    [J]. HISTOPATHOLOGY, 2022, 80 (01) : 4 - 18
  • [8] Calcification and ossification in conventional schwannoma: A clinicopathologic study of 32 cases
    Din, Nasir U.
    Fritchie, Karen
    Tariq, Muhammad U.
    Ahmed, Arsalan
    Ahmad, Zubair
    [J]. NEUROPATHOLOGY, 2020, 40 (02) : 144 - 151
  • [9] Identification of a novel MTAP-RAF1 fusion in a soft tissue sarcoma
    Hicks, J. Kevin
    Henderson-Jackson, Evita
    Duggan, Julia
    Joyce, David M.
    Brohl, Andrew S.
    [J]. DIAGNOSTIC PATHOLOGY, 2018, 13
  • [10] CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles
    Jain, P.
    Fierst, T. M.
    Han, H. J.
    Smith, T. E.
    Vakil, A.
    Storm, P. B.
    Resnick, A. C.
    Waanders, A. J.
    [J]. ONCOGENE, 2017, 36 (45) : 6348 - 6358
123