Laser-tissue interaction simulation considering skin-specific data to predict photothermal damage lesions during laser irradiation

被引:7
作者
Kim, Hyo-Jin [1 ]
Um, Seung-Hoon [2 ,3 ]
Kang, Yong Guk [4 ]
Shin, Minwoo [1 ]
Jeon, Hojeong [3 ]
Kim, Beop-Min [4 ]
Lee, Deukhee [5 ,6 ]
Yoon, Kyungho [1 ]
机构
[1] Yonsei Univ, Sch Math & Comp Computat Sci & Engn, Seoul 03722, South Korea
[2] Laval Univ, Dept Min Met & Mat Engn, Quebec City, PQ G1V0A6, Canada
[3] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
[4] Korea Univ, Coll Hlth Sci, Dept Bioconvergence Engn, Seoul 02841, South Korea
[5] Korea Inst Sci & Technol, Ctr Healthcare Robot, Seoul 02792, South Korea
[6] Yonsei Univ, Yonsei KIST Convergence Res Inst, Seoul 03722, South Korea
基金
新加坡国家研究基金会;
关键词
laser irradiation; optical coherence tomography; finite difference time-domain; Monte Carlo simulation; OPTICAL-PROPERTIES; 8; WAVELENGTHS; MODEL; TRANSPORT; DERMIS; VALIDATION; PIG;
D O I
10.1093/jcde/qwad033
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
This study aimed to develop a simulation model that accounts for skin-specific properties in order to predict photothermal damage during skin laser treatment. To construct a computational model, surface geometry information was obtained from an optical coherence tomography image, and the absorption coefficient of the skin was determined through spectrophotometry. The distribution of the internal light dose inside the skin medium was calculated using the light propagation model based on the Monte Carlo method. The photothermal response due to the absorption of laser light was modeled by a finite difference time domain model to solve the bio-heat transfer equation. The predicted depth and area of the damaged lesions from the simulation model were compared to those measured in ex vivo porcine skin. The present simulation model gave acceptable predictions with differences of approximately similar to 10% in both depth and area.
引用
收藏
页码:947 / 958
页数:12
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