Cutibacterium (Formerly Propionibacterium) acnes Keratitis: A Review

被引:4
作者
Ashby, Nathaniel S. S. [1 ]
Johnson, Taylor J. J. [2 ]
Castillo-Ronquillo, Yasmyne [3 ]
Payne, Carter J. J. [3 ,4 ]
Davenport, Connor [3 ]
Hoopes, Phillip C. C. [3 ]
Moshirfar, Majid [3 ,5 ,6 ]
机构
[1] Creighton Univ, Sch Med, Dr CC & Mabel L Criss Hlth Sci Complex II,2621 Bur, Omaha, NE 68178 USA
[2] Univ Utah, Spencer Fox Eccles Sch Med, Salt Lake City, UT USA
[3] Hoopes Vis, Hoopes Vis Res Ctr, Draper, UT USA
[4] Case Western Reserve Univ, Sch Med, Cleveland, OH USA
[5] Univ Utah, John A Moran Eye Ctr, Sch Med, Dept Ophthalmol & Visual Sci, Salt Lake City, UT USA
[6] Utah Lions Eye Bank, Murray, UT USA
来源
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE | 2023年 / 49卷 / 05期
关键词
Cutibacterium acnes; Propionibacterium acnes; Keratitis; Corneal infection; Corneal ulcer; INFECTIOUS KERATITIS; BACTERIAL KERATITIS; ANTIMICROBIAL SUSCEPTIBILITY; ANTIBIOTIC SUSCEPTIBILITY; MICROBIAL KERATITIS; SHIFTING TRENDS; MULTIPLEX PCR; PREVALENCE; RESISTANCE; ETIOLOGY;
D O I
10.1097/ICL.0000000000000975
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Infectious keratitis is a devastating cause of vision loss worldwide. Cutibacterium acnes (C. acnes), a commensal bacterium of the skin and ocular surface, is an underrecognized but important cause of bacterial keratitis. This review presents the most comprehensive and up-to-date information for clinicians regarding the risk factors, incidence, diagnosis, management, and prognosis of C. acnes keratitis (CAK). Risk factors are similar to those of general bacterial keratitis and include contact lens use, past ocular surgery, and trauma. The incidence of CAK may be approximately 10%, ranging from 5% to 25% in growth-positive cultures. Accurate diagnosis requires anaerobic blood agar and a long incubation period (>= 7 days). Typical clinical presentation includes small (<2 mm) ulcerations with deep stromal infiltrate causing an anterior chamber cell reaction. Small, peripheral lesions are usually resolved, and patients recover a high visual acuity. Severe infections causing VA of 20/200 or worse are common and often do not significantly improve even after treatment. Vancomycin is considered the most potent antibiotic against CAK, although other antibiotics such as moxifloxacin and ceftazidime are more commonly used as first-line treatment.
引用
收藏
页码:212 / 218
页数:7
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