Ovarian Cancer and Glutamine Metabolism

被引：14

作者：

Fasoulakis, Zacharias ^{[1
]}

Koutras, Antonios ^{[1
]}

Ntounis, Thomas ^{[1
]}

Prokopakis, Ioannis ^{[1
]}

Perros, Paraskevas ^{[1
]}

Chionis, Athanasios ^{[2
]}

Sapantzoglou, Ioakeim ^{[1
]}

Katrachouras, Alexandros ^{[3
]}

Konis, Kyriakos ^{[4
]}

Samara, Athina A. ^{[5
]}

Valsamaki, Asimina ^{[6
]}

Palios, Vasileios-Chrysovalantis ^{[7
]}

Symeonidis, Panagiotis ^{[8
]}

Nikolettos, Konstantinos ^{[9
]}

Pagkalos, Athanasios ^{[10
]}

Sotiriou, Sotirios ^{[11
]}

Theodora, Marianna ^{[1
]}

Antsaklis, Panos ^{[1
]}

Daskalakis, Georgios ^{[1
]}

Kontomanolis, Emmanuel N. ^{[9
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Gen Hosp Athens ALEXANDRA, Dept Obstet & Gynecol 1, Lourou & Vasilissis Sofias Ave, Athens 11528, Greece

[2] Laiko Gen Hosp Athens, Dept Obstet & Gynecol, Agiou Thoma 17, Athens 11527, Greece

[3] Univ Ioannina, Univ Gen Hosp Ioannina, Dept Obstet & Gynecol, Stavrou Niarchou Str, Ioannina 45500, Greece

[4] Gen Hosp Arta, Dept Obstet & Gynecol, Arta 47100, Greece

[5] Univ Hosp Larissa, Dept Embryol, Larisa 41110, Greece

[6] Gen Hosp Larisa, Dept Internal Med, Tsakalof 1, Larisa 41221, Greece

[7] Univ Gen Hosp Larissa, Dept Obstet & Gynecol, Larisa 41110, Greece

[8] Univ Gen Hosp Alexandroupolis, Dept Obstet & Gynecol, 6th Klm Alexandroupolis Makris, Alexandroupolis 68100, Greece

[9] Democritus Univ Thrace, Dept Obstet & Gynecol, 6th Km Alexandroupolis Makris, Alexandroupolis 68100, Greece

[10] Gen Hosp Xanthi, Dept Obstet & Gynecol, Neapoli 67100, Xanthi, Greece

[11] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Embryol, Larisa 41110, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期

关键词：

ovarian cancer; glutamine; cancer cell; metabolism; cancer treatment; GLUCOSE; CELLS; PROLIFERATION;

D O I：

10.3390/ijms24055041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements. There is mounting evidence that there is a link between glutamine metabolism and the proliferation of cancer cells, demonstrating that glutamine metabolism is a vital mechanism for all cellular processes, including the development of cancer. Detailed knowledge regarding its degree of engagement in numerous biological processes across distinct cancer types is still lacking, despite the fact that such knowledge is necessary for comprehending the differentiating characteristics of many forms of cancer. This review aims to examine data on glutamine metabolism and ovarian cancer and identify possible therapeutic targets for ovarian cancer treatment.

引用

页数：10

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