Combination venetoclax and olverembatinib (HQP1351) as a successful therapeutic strategy for relapsed/refractory (R/R) mixed-phenotype blast phase of chronic myeloid leukemia

被引:2
|
作者
Zhang, Tongtong [1 ,2 ]
Zhou, Haixia [1 ,2 ]
Xu, Mingzhu [1 ,2 ]
Qian, Chongsheng [1 ,2 ]
Sun, Aining [1 ,2 ]
Wu, Depei [1 ,2 ]
Xue, Shengli [1 ,2 ]
机构
[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Natl Clin Res Ctr Hematol Dis, Suzhou 215000, Peoples R China
[2] Soochow Univ, Inst Blood & Marrow Transplantat, Collaborat Innovat Ctr Hematol, Suzhou 215000, Peoples R China
基金
中国国家自然科学基金;
关键词
D O I
10.1007/s00277-023-05110-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:973 / 975
页数:3
相关论文
共 50 条
  • [21] Dose-Reduced FLA-IDA in Combination with Venetoclax Is an Effective and Safe Salvage Therapy in Relapsed and Refractory Acute Myeloid Leukemia (R/R AML)
    Schoenrock, Martin
    Sonnemann, Piet
    Michalowski, Nina
    Heuser, Michael
    Thol, Felicitas
    Ayuk, Francis Ayuketang
    Wolschke, Christine
    Klyuchnikov, Evgeny
    Bokemeyer, Carsten
    Fiedler, Walter
    Cichutek, Sophia
    CANCERS, 2024, 16 (22)
  • [22] A Phase 2 Study of Duvelisib and Venetoclax in Patients with Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) or Richter's Syndrome (RS)
    Crombie, Jennifer L.
    Ryan, Christine E.
    Ren, Yue
    Tyekucheva, Svitlana
    Carey, Celeste
    Zou, Aaron
    Normilus, Samantha
    Montegaard, Josie
    Soumerai, Jacob D.
    Bhandari, Shruti
    Arnason, Jon E.
    Alencar, Alvaro J.
    Kim, Austin I.
    Parry, Erin M.
    Armand, Philippe
    Fisher, David C.
    Brown, Jennifer R.
    Davids, Matthew S.
    BLOOD, 2024, 144 : 4628 - 4629
  • [23] Subgroup analysis from a phase II trial of ponatinib and blinatumomab in relapsed/refractory (R/R) Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia in lymphoid blast phase
    Zoghbi, Marianne
    Jabbour, Elias
    Haddad, Fadi
    Short, Nicholas James
    Nasnas, Cedric Christophe
    Macaron, Walid
    Nasr, Lewis Fady
    Jain, Nitin
    Montalban-Bravo, Guillermo
    Kadia, Tapan M.
    Daver, Naval Guastad
    Chien, Kelly Sharon
    Valero, Yesid Alvarado
    Issa, Ghayas C.
    Mayor, Ejiroghene
    Deen, Wuliamatu
    Thankachan, Jennifer
    Garris, Rebecca
    Ravandi, Farhad
    Kantarjian, Hagop M.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [24] Correction: Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial
    Qian Jiang
    Zongru Li
    Yazhen Qin
    Weiming Li
    Na Xu
    Bingcheng Liu
    Yanli Zhang
    Li Meng
    Huanling Zhu
    Xin Du
    Suning Chen
    Yang Liang
    Yu Hu
    Xiaoli Liu
    Yongping Song
    Lichuang Men
    Zi Chen
    Qian Niu
    Hengbang Wang
    Ming Lu
    Dajun Yang
    Yifan Zhai
    Xiaojun Huang
    Journal of Hematology & Oncology, 16
  • [25] Tuspetinib Myeloid Kinase Inhibitor Safety and Efficacy As Monotherapy and Combined with Venetoclax in Phase 1/2 Trial of Patients with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)
    Daver, Naval
    Lee, Kyoo Hyung
    Choi, Yunsuk
    Jonas, Brian A.
    Arellano, Martha
    Koller, Paul B.
    Jung, Chul W.
    Sohn, Sang Kyun
    Fathi, Amir T.
    Lee, Jeong-Ok
    Yoon, Sung-Soo
    Watts, Justin M.
    Vachhani, Pankit
    Shin, Ho-Jin
    Hu, Jia
    Sinha, Ranjeet
    Khan, Nawazish
    Rice, William G.
    Bejar, Rafael
    BLOOD, 2023, 142
  • [26] Novel BCR-ABL1 Tyrosine Kinase Inhibitor (TKI) HQP1351 (Olverembatinib) Is Efficacious and Well Tolerated in Patients with T315I-Mutated Chronic Myeloid Leukemia (CML): Results of Pivotal (Phase II) Trials
    Jiang, Qian
    Huang, Xiaojun
    Chen, Zi
    Niu, Qian
    Shi, Dayu
    Li, Zongru
    Hou, Yue
    Hu, Yu
    Li, Weiming
    Liu, Xiaoli
    Xu, Na
    Song, Yongping
    Zhang, Yanli
    Meng, Li
    Hong, Zhenya
    Liu, Bingcheng
    Zeng, Shan
    Men, Lichuang
    Li, Yan
    Chen, Suning
    Xue, Mengxing
    Zhu, Huanling
    Li, He
    Du, Xin
    Lou, Jin
    Zhang, Xiaohan
    Liang, Yang
    Dai, Yujun
    Lu, Ming
    Wang, Hengbang
    Ji, Jiao
    Yue, Changai
    Yang, Dajun
    Zhai, Yifan
    BLOOD, 2020, 136
  • [27] Overcoming Venetoclax (Ven) Resistance through Glutamine (Gln) Depletion: Final Analysis of the Phase 1 Trial of Ven and Pegcrisantaspase (PegC) Combination in Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML)
    Liu, Yuchen
    Bollino, Dominique
    Bah, Osman M.
    Strovel, Erin T.
    Zarrabi, Jinoos
    Philip, Sunita
    Mostafa, Ezzat
    Lapidus, Rena G.
    Baer, Maria R.
    Niyongere, Sandrine
    Duong, Vu H.
    Dougherty, Christine C.
    Caprinolo, Katherine
    Emadi, Ashkan
    BLOOD, 2023, 142
  • [28] MURANO Trial Establishes Feasibility of Time-Limited Venetoclax-Rituximab (VenR) Combination Therapy in Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)
    Seymour, John F.
    Kipps, Thomas J.
    Eichhorst, Barbara
    Hillmen, Peter
    D'Rozario, James
    Assouline, Sarit
    Owen, Carolyn
    Robak, Tadeusz
    de la Serna, Javier
    Jaeger, Ulrich
    Cartron, Guillaume
    Montillo, Marco
    Lamanna, Nicole
    Verdugo, Maria E.
    Punnoose, Elizabeth A.
    Jiang, Yanwen
    Wang, Jue
    Boyer, Michelle
    Humphrey, Kathryn
    Mobasher, Mehrdad
    Kater, Arnon P.
    BLOOD, 2018, 132
  • [29] Updated Results of Pivotal Phase 2 Trials of Olverembatinib (HQP1351) in Patients (Pts) with Tyrosine Kinase Inhibitor (TKI)-Resistant Chronic- and Accelerated-Phase Chronic Myeloid Leukemia (CML-CP and CML-AP) with T315I Mutation
    Jiang, Qian
    Li, Zongru
    Hou, Yue
    Hu, Yu
    Li, Weiming
    Liu, Xiaoli
    Xu, Na
    Zhang, Yanli
    Song, Yongping
    Meng, Li
    Hong, Zhenya
    Liu, Bingcheng
    Li, Yan
    Chen, Suning
    Xue, Mengxing
    Zhu, Huanling
    Li, He
    Du, Xin
    Lou, Jin
    Zhang, Xiaohan
    Liang, Yang
    Dai, Yu-Jun
    Chen, Zi
    Niu, Qian
    Men, Lichuang
    Yang, Dajun
    Zhai, Yifan
    Huang, Xiao-Jun
    BLOOD, 2022, 140
  • [30] Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial (vol 15, 113, 2022)
    Jiang, Qian
    Li, Zongru
    Qin, Yazhen
    Li, Weiming
    Xu, Na
    Liu, Bingcheng
    Zhang, Yanli
    Meng, Li
    Zhu, Huanling
    Du, Xin
    Chen, Suning
    Liang, Yang
    Hu, Yu
    Liu, Xiaoli
    Song, Yongping
    Men, Lichuang
    Chen, Zi
    Niu, Qian
    Wang, Hengbang
    Lu, Ming
    Yang, Dajun
    Zhai, Yifan
    Huang, Xiaojun
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)