Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model

被引：5

作者：

Syu, Guan-Da ^{[1
,2
,3
,12
]}

Sutandy, F. X. Reymond ^{[4
]}

Chen, Kevin ^{[5
]}

Cheng, Yawei ^{[6
,7
,8
]}

Chen, Chien-Sheng ^{[9
,13
]}

Shih, Jean C. ^{[5
,10
,11
,14
]}

机构：

[1] Natl Cheng Kung Univ, Dept Biotechnol & Bioind Sci, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Int Ctr Wound Repair & Regenerat, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Med Device Innovat Ctr, Tainan, Taiwan

[4] Goethe Univ, Inst Biochem 2, Theodor Stern Kai 7, Frankfurt, Germany

[5] Univ Southern Calif, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA USA

[6] Natl Yang Ming Univ Hosp, Dept Phys Med & Rehabil, Yilan, Taiwan

[7] Natl Yang Ming Univ, Inst Neurosci, Brain Res Ctr, Taipei, Taiwan

[8] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan

[9] Natl Cheng Kung Univ, Coll Med, Dept Food Safety Hyg & Risk Management, Tainan, Taiwan

[10] Univ Southern Calif, Taiwan Ctr Translat Res, USC, Los Angeles, CA USA

[11] Univ Southern Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA USA

[12] Natl Cheng Kung Univ, Dept Biotechnol & Bioind Sci, 1 Univ Rd, Tainan 701, Taiwan

[13] Natl Cheng Kung Univ, Dept Food Safety Hyg & Risk Management, 1 Univ Rd, Tainan 701, Taiwan

[14] Univ Southern Calif, Dept Pharmacol & Pharmaceut Sci, 1985 Zonal Ave, Los Angeles, CA 90089 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2023年 / 107卷

关键词：

Monoamine oxidase A (MAO A); MAO A knockout mice; Autism spectrum disorder (ASD); Serotonin; Antibody profiling; Human proteome microarrays; Serology; NEUTROPHIL RECRUITMENT; BRAIN-SEROTONIN; POINT MUTATION; PROMOTES; BEHAVIOR; GENE; SCHIZOPHRENIA; ANTIBODIES; PHENOTYPE; SYSTEM;

D O I：

10.1016/j.bbi.2022.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoamine oxidase A (MAO A) is the critical enzyme to degrade serotonin in the brain and the knockout mouse exhibits hyperserotonemia and abnormalities that are observed in autism spectrum disorder (ASD). Thus, the MAO A knockout mouse is a valuable model for studying neurological and behavioral impairments in ASD. Based on the immune dysfunction hypothesis, dysregulated humoral immunity may cause neurological impairments. To address this hypothesis, we use high-density proteome microarray to profile the serum antibodies in both wild-type and MAO A knockout mice. The distingue autoantibody signatures were observed in the MAO A knockout and wild-type controls and showed 165 up-regulated and 232 down-regulated autoantibodies. The up -regulated autoantibodies were prone to target brain tissues while down-regulated ones were enriched in sex organs. The identified autoantibodies help bridge the gap between ASD mouse models and humoral immunity, not only yielding insights into the pathological mechanisms but also providing potential biomarkers for trans-lational research in ASD.

引用

页码：193 / 200

页数：8

共 46 条

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