Purpose - Even though social media (SM) has been explored in-depth, its role remains unclear regarding short- and long-term preventive attitudes in global health emergencies. To fill this gap, the Stimulus-Organism-Response framework aims to clarify the social media exposure mission in acknowledging risk perception and triggering preventive attitudes and behaviors toward COVID-19 and general vaccination. Design/methodology/approach - The authors conducted an explanatory-predictive study on 480 Romanian students, using partial least squares structural equation modeling, and performed model evaluation, multi-group, model selection, and importance-performance map analyses. Findings- The study provides insights in understanding significant relationships and drivers explaining and predicting attitudes towards vaccines. The main relationships are between fear and risk perception; risk and preventive attitudes and behaviors; and vaccination degree and attitudes to vaccines. The most important factor is the vaccination degree and media exposure is the most performant. Practical implications - Developing and applying regulations and communication strategies for quality mass information may positively increase attitudes toward vaccines by indirectly enforcing the main drivers. Social implications - Organizations, authorities, and opinion leaders must have a coherent supportive presence in media. Originality/value - This study filled the literature gap by building a generic theoretical and empirical proven framework that investigates the mediated effect towards vaccines of all media types by COVID-19 experience and vaccination degree.