Trastuzumab conjugated PEG - Fe3O4@Au nanoparticle as an MRI biocompatible nano-contrast agent

被引：14

作者：

Malekzadeh, Reza ^{[1
,2
]}

Abdollahi, Behnaz Babaye ^{[2
]}

Ghorbani, Marjan ^{[3
]}

Islamian, Jalil Pirayesh ^{[2
]}

Mortezazadeh, Tohid ^{[2
]}

机构：

[1] Tabriz Univ Med Sci, Med Radiat Sci Res Team, Tabriz, Iran

[2] Tabriz Univ Med Sci, Sch Med, Dept Med Phys, Tabriz, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2023年 / 72卷 / 10期

关键词：

Contrast media; magnetic resonance imaging; relaxivity; trastuzumab; IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; GOLD NANOPARTICLES; CANCER-CELLS; CO-DELIVERY; DOXORUBICIN; PH; SHELL; T-1;

D O I：

10.1080/00914037.2022.2058944

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel targeted tumor contrast agent in magnetic resonance imaging (MRI) was synthesized based on Fe3O4@Au nanoparticle coated with polyethylene glycol (PEG) and decorated with trastuzumab (TZ). The prepared system was fully characterized, and relaxivity, cytotoxicity, colloidal stability, blood compatibility, in vitro cell targeting ability, cytotoxicity, and in vivo MR contrast enhancement were evaluated. The developed system with a size of about 30 nm exhibited excellent stability, blood compatibility, proper relaxivity, negligible in vitro cytotoxicity, and suitable in vivo negative contrast enhancement. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system to be suggested as an encouraging candidate for accurate cancer diagnosis.

引用

页码：759 / 770

页数：12

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