Renal tubular dysfunction in COVID-19 patients

被引:6
作者
Aroca-Martinez, Gustavo [1 ,2 ,3 ]
Avendano-Echavez, Lil [1 ]
Garcia, Carlos [1 ]
Ripoll, Daniela [1 ]
Dianda, Daniela [2 ]
Cadena-Bonfanti, Andres [1 ,2 ]
Musso, Carlos G. [1 ,4 ]
机构
[1] Univ Simon, Fac Ciencias La Salud, Barranquilla, Colombia
[2] Clin La Costa, Dept Nephrol, Barranquilla, Colombia
[3] Univ Norte, Barranquilla, Colombia
[4] Hosp Italiano Buenos Aires, Res Dept, C1199, RA-4265 Potosi, Buenos Aires, Argentina
关键词
COVID-19; Electrolytes; Tubular function;
D O I
10.1007/s11845-022-02993-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction SARS-CoV-2 infection can affect other organs aside from those of respiratory system, particularly the kidney, heart, blood, digestive tract, and nervous system. COVID-19 renal compromise consists of different syndromes since proteinuria, hematuria, and acute kidney injury (AKI), until chronic kidney disease. Since COVID-19-induced renal tubular damage has been described as a potential antecedent condition to AKI installation, it was decided to evaluate how COVID-19 affects tubular function. Materials and method Serum inflammatory parameters, urinalysis, and classical urinary indexes in COVID-19 admitted patients who had neither AKI nor chronic kidney disease (CKD) were evaluated. Statistical analysis was performed by applying Student t test. Results Renal tubular function was evaluated in 41 COVID-19 admitted patients who had neither AKI nor CKD. Patients' mean age was 56 years, males (79%), and with normal creatininemia (0.8 +/- 0.2 mg/dL) and eGFR (105.7 +/- 6.5 mL/min) values. It was found mild hypocalcemia and a relative increased fractional excretion (FE) of sodium, FE of calcium, FE of phosphorus, calcium-creatinine index, urinary osmolarity, and relative alkaline urine pH values. Conclusion Tubular dysfunction was documented in COVID-19 patients.
引用
收藏
页码:923 / 927
页数:5
相关论文
共 50 条
[41]   Olfactory dysfunction in patients after recovering from COVID-19 [J].
Otte, Martin Sylvester ;
Eckel, Hans Nikolaus Caspar ;
Poluschkin, Leonard ;
Klussmann, Jens Peter ;
Luers, Jan Christoffer .
ACTA OTO-LARYNGOLOGICA, 2020, 140 (12) :1032-1035
[42]   Pulmonary Endothelial Dysfunction and Thrombotic Complications in Patients with COVID-19 [J].
Rodriguez, Cristina ;
Luque, Neus ;
Blanco, Isabel ;
Sebastian, Laura ;
Albert Barbera, Joan ;
Peinado, Victor, I ;
Tura-Ceide, Olga .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2021, 64 (04) :407-415
[43]   Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction [J].
Gonzalez, Filipe Andre ;
Angelo-Dias, Miguel ;
Martins, Catarina ;
Gomes, Rui ;
Bacariza, Jacobo ;
Fernandes, Antero ;
Borrego, Luis Miguel .
JOURNAL OF CLINICAL MEDICINE, 2022, 11 (07)
[44]   Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review [J].
Luca Giovanella ;
Rosaria M. Ruggeri ;
Petra Petranović Ovčariček ;
Alfredo Campenni ;
Giorgio Treglia ;
Desiree Deandreis .
Clinical and Translational Imaging, 2021, 9 :233-240
[45]   Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19 [J].
Yao, Yang ;
Liu, Zhu-Jun ;
Zhang, Yu-Kun ;
Sun, Hui-Jun .
WORLD JOURNAL OF GASTROENTEROLOGY, 2022, 28 (48) :6811-6826
[46]   Prevalence of smell and taste dysfunction in patients infected with COVID-19 [J].
Kucukcan, Nagehan Erdogmus ;
Kucukcan, Akif .
CUKUROVA MEDICAL JOURNAL, 2022, 47 (02) :861-869
[47]   A tool for the psychophysical assessment of olfactory dysfunction in patients with COVID-19 [J].
Kim, Kyung Soo ;
Min, Hyun Jin .
ENT-EAR NOSE & THROAT JOURNAL, 2024, 103 (1_SUPPL) :102S-104S
[48]   Pathogenesis of taste impairment and salivary dysfunction in COVID-19 patients [J].
Okada, Yasuo ;
Yoshimura, Ken ;
Toya, Shuji ;
Tsuchimochi, Makoto .
JAPANESE DENTAL SCIENCE REVIEW, 2021, 57 :111-122
[49]   Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database [J].
Abrahams, Alferso C. ;
Noordzij, Marlies ;
Goffin, Eric ;
Sanchez, J. Emilio ;
Franssen, Casper F. M. ;
Vart, Priya ;
Jager, Kitty J. ;
van Agteren, Madelon ;
Covic, Adrian ;
Mitra, Sandip ;
Basile, Carlo ;
Konings, Constantijn ;
Hemmelder, Marc H. ;
Duivenvoorden, Raphael ;
Hilbrands, Luuk B. ;
Gansevoort, Ron T. .
PERITONEAL DIALYSIS INTERNATIONAL, 2023, 43 (01) :23-36
[50]   The Role of Immunomodulatory Therapy with Oxiris in COVID-19 with Renal Failure and Immune Dysfunction [J].
Trasobares, Nerea Quilez ;
Gonzalez-Fernandez, Maria ;
Barea-Mendoza, Jesus Abelardo ;
Arias-Verdu, Maria Dolores ;
Barrueco-Francioni, Jesus Emilio ;
Seller-Perez, Gemma ;
Molina-Collado, Zaira ;
Gonzalez- de Aledo, Amanda Lesmes ;
Herrera-Gutierrez, Manuel ;
Riera, Jose Angel Sanchez-Izquierdo .
BLOOD PURIFICATION, 2024, 53 (10) :804-812