Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet

被引:1
作者
Batdorf, Heidi M. [1 ,2 ]
Lawes, Luz de Luna [1 ]
Cassagne, Gabrielle A. [1 ]
Fontenot, Molly S. [1 ]
Harvey, Innocence C. [1 ]
Richardson, Jeremy T. [1 ]
Burk, David H. [1 ]
Dupuy, Samuel D. [3 ]
Karlstad, Michael D. [3 ]
Salbaum, J. Michael [1 ]
Staszkiewicz, Jaroslaw [1 ]
Beyl, Robbie [1 ]
Ghosh, Sujoy [1 ]
Burke, Susan J. [1 ]
Collier, J. Jason [1 ,2 ,4 ]
机构
[1] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
[2] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA USA
[3] Univ Tennessee, Hlth Sci Ctr, Grad Sch Med, Dept Surg, Knoxville, TN USA
[4] Louisiana State Univ, Sch Med, New Orleans, LA USA
关键词
autoimmunity; diabetes; diet; microbiome; non-obese diabetic (NOD) mouse model; obesity; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; ANIMAL-MODELS; METABOLIC PROGRESSION; GUT MICROBIOTA; RISK-FACTORS; TYPE-1; OBESITY; SUCROSE;
D O I
10.1111/dom.15522
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimType 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka 'chow') diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice.MethodsFemale NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group.ResultsNOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had an accelerated onset of hyperglycaemia compared to the matched low-fat diet. There was no change in food intake, energy expenditure, or physical activity within each respective dietary group. Microbiome changes were driven by diet type, with chow diets clustering similarly, while refined low- and high-fat bacterial diversity also grouped closely. In the defined dietary cohort, liver gene expression changes in high-fat-fed mice were consistent with a greater frequency of hyperglycaemia and impaired glucose tolerance.ConclusionGlucose intolerance is associated with an enhanced frequency of hyperglycaemia in female NOD mice fed a defined high-fat diet. Using an appropriate matched control diet is an essential experimental variable when studying changes in microbiome composition and diet as a modifier of disease risk.
引用
收藏
页码:2158 / 2166
页数:9
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