Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet
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作者:
Batdorf, Heidi M.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Batdorf, Heidi M.
[1
,2
]
Lawes, Luz de Luna
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Lawes, Luz de Luna
[1
]
Cassagne, Gabrielle A.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Cassagne, Gabrielle A.
[1
]
Fontenot, Molly S.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Fontenot, Molly S.
[1
]
Harvey, Innocence C.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Harvey, Innocence C.
[1
]
Richardson, Jeremy T.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Richardson, Jeremy T.
[1
]
Burk, David H.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Burk, David H.
[1
]
Dupuy, Samuel D.
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机构:
Univ Tennessee, Hlth Sci Ctr, Grad Sch Med, Dept Surg, Knoxville, TN USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Dupuy, Samuel D.
[3
]
Karlstad, Michael D.
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Univ Tennessee, Hlth Sci Ctr, Grad Sch Med, Dept Surg, Knoxville, TN USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Karlstad, Michael D.
[3
]
Salbaum, J. Michael
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Salbaum, J. Michael
[1
]
Staszkiewicz, Jaroslaw
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Staszkiewicz, Jaroslaw
[1
]
Beyl, Robbie
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Beyl, Robbie
[1
]
Ghosh, Sujoy
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Ghosh, Sujoy
[1
]
Burke, Susan J.
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Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Burke, Susan J.
[1
]
Collier, J. Jason
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机构:
Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA USA
Louisiana State Univ, Sch Med, New Orleans, LA USAPennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Collier, J. Jason
[1
,2
,4
]
机构:
[1] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
[2] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA USA
[3] Univ Tennessee, Hlth Sci Ctr, Grad Sch Med, Dept Surg, Knoxville, TN USA
[4] Louisiana State Univ, Sch Med, New Orleans, LA USA
AimType 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka 'chow') diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice.MethodsFemale NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group.ResultsNOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had an accelerated onset of hyperglycaemia compared to the matched low-fat diet. There was no change in food intake, energy expenditure, or physical activity within each respective dietary group. Microbiome changes were driven by diet type, with chow diets clustering similarly, while refined low- and high-fat bacterial diversity also grouped closely. In the defined dietary cohort, liver gene expression changes in high-fat-fed mice were consistent with a greater frequency of hyperglycaemia and impaired glucose tolerance.ConclusionGlucose intolerance is associated with an enhanced frequency of hyperglycaemia in female NOD mice fed a defined high-fat diet. Using an appropriate matched control diet is an essential experimental variable when studying changes in microbiome composition and diet as a modifier of disease risk.
机构:
Natl Inst Hlth & Welf, Dept Hlth, Unit Nutr, POB 30, Helsinki 00271, Finland
Univ Tampere, Sch Hlth Sci, Tampere, Finland
Sci Ctr Pirkanmaa Hosp Dist, Tampere, Finland
Univ Tampere, Ctr Child Hlth Res, Tampere, Finland
Tampere Univ Hosp, Tampere, FinlandNatl Inst Hlth & Welf, Dept Hlth, Unit Nutr, POB 30, Helsinki 00271, Finland
机构:
Natl Inst Hlth & Welf, Dept Hlth, Unit Nutr, POB 30, Helsinki 00271, Finland
Univ Tampere, Sch Hlth Sci, Tampere, Finland
Sci Ctr Pirkanmaa Hosp Dist, Tampere, Finland
Univ Tampere, Ctr Child Hlth Res, Tampere, Finland
Tampere Univ Hosp, Tampere, FinlandNatl Inst Hlth & Welf, Dept Hlth, Unit Nutr, POB 30, Helsinki 00271, Finland