Gram-negative Bacteria are Associated With Sensorineural Hearing Loss in Chronic Otitis Media

被引:1
|
作者
Lou, Jintao [1 ,2 ]
He, Wuhui [1 ,2 ]
Cui, Bozhen [1 ,2 ]
Wu, Fan [1 ,2 ]
Liu, Wei [1 ,2 ]
Deng, Jingman [1 ,2 ]
Huang, Yan [1 ,2 ]
Zhang, Zhigang [1 ,2 ,3 ]
Si, Yu [1 ,2 ,3 ]
机构
[1] Sun Yat sen Univ, Sun Yat sen Mem Hosp, Dept Otolaryngol, Guangzhou, Peoples R China
[2] Sun Yat sen Univ, Inst Hearing & Speech Language Sci, Guangzhou, Peoples R China
[3] Sun Yat sen Univ, Sun Yat sen Mem Hosp, Dept Otolaryngol, 107 Yanjiang West Rd, Guangzhou 510120, Peoples R China
来源
LARYNGOSCOPE | 2024年 / 134卷 / 07期
关键词
bacterial infection; chronic otitis media (COM); circulating monocytes; SNHL; RISK-FACTORS; INNER-EAR; SEPSIS;
D O I
10.1002/lary.31322
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Object: Chronic otitis media (COM) is an inflammatory disease that commonly presents with otorrhea and hearing loss. Bacteria-induced inflammation can cause inner ear damage, leading to sensorineural hearing loss (SNHL). This study aimed to compare the prevalence and severity of SNHL in patients with gram-negative versus gram-positive cultures and examine associations between the concentrations of circulating monocytes and neutrophils with bacteria species and SNHL. Methods: This was a retrospective study. Cholesteatoma or chronic suppurative otitis media patients with otorrhea were enrolled. Middle ear secretions were collected using sterile swabs under an otoscope, and sent for bacterial detection within 30 min. Pure tone audiometry and circulating leukocyte counts were recorded and analyzed in patients infected with different pathogens. Logistic regression analysis was used to identify the risk factors associated with SNHL. Results: A total of 137 patients were enrolled, including 45 patients infected with gram-negative bacteria, 41 with gram-positive bacteria, 20 with polymicrobial infection, and 31 with no bacterial growth. Logistic regression analysis showed that bacterial culture positive infections (OR = 7.265, 95% CI 2.219-23.786, p = 0.001) were an independent risk factor for SNHL. Patients with gram-negative bacteria had higher risks of SNHL (p < 0.0001) and more severe hearing loss (p = 0.005) than those with gram-positive bacteria. COM patients infected with gram-negative bacteria showed an increase in circulating monocytes, which correlated with the occurrence of SNHL (p = 0.0343). Conclusion: Gram-negative bacteria are associated with elevated circulating monocyte counts and have a higher risk of severe SNHL.
引用
收藏
页码:3335 / 3341
页数:7
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