Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design

被引：53

作者：

Cheng, Yi ^{[1
]}

Tan, Guohua ^{[2
]}

Zhu, Qihui ^{[3
]}

Wang, Chun ^{[1
]}

Ruan, Guangcong ^{[1
]}

Ying, Senhong ^{[1
]}

Qie, Jinlong ^{[3
,4
]}

Hu, Xiaofei ^{[5
]}

Xiao, Zhifeng ^{[1
]}

Xu, Fenghua ^{[1
]}

Chen, Lu ^{[1
]}

Chen, Minjia ^{[1
]}

Pei, Yang ^{[3
,4
]}

Zhang, Hao ^{[1
]}

Tian, Yuting ^{[1
]}

Chen, Dongfeng ^{[1
]}

Liu, Xingyin ^{[3
,4
]}

Huang, Heqing ^{[2
,7
]}

Wei, Yanling ^{[1
,6
]}

机构：

[1] Army Med Univ, Mil Med Univ 3, Daping Hosp, Dept Gastroenterol,Chongqing Key Lab Digest Malign, Chongqing, Peoples R China

[2] Army Med Univ, Southwest Hosp, Dept Neurol, Chongqing, Peoples R China

[3] Nanjing Med Univ, Key Lab Pathogen Jiangsu Prov, Microbiol Div, Dept Pathogen Biol, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Affiliated Suzhou Hosp, Suzhou Municipal Hosp Gusu Sch, Nanjing, Jiangsu, Peoples R China

[5] Army Med Univ, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China

[6] Army Med Univ, Mil Med Univ 3, Daping Hosp, Chongqing 400042, Peoples R China

[7] Army Med Univ, Southwest Hosp, Chongqing 400038, Peoples R China

来源：

GUT MICROBES | 2023年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; clinical trial; fecal microbiota transplantation; gut microbiota; microbiota-gut-brain axis; GUT MICROBIOME; RISK;

D O I：

10.1080/19490976.2023.2284247

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at the Department of Neurology, Army Medical University Southwest Hospital in China (ChiCTR1900021405) from February 2019 to December 2019. Fifty-six participants with mild to moderate PD (Hoehn-Yahr stage 1-3) were randomly assigned to the FMT and placebo group, 27 patients in the FMT group and 27 in the placebo group completed the whole trial. During the follow-up, no severe adverse effect was observed, and patients with FMT treatment showed significant improvement in PD-related autonomic symptoms compared with the placebo group at the end of this trial (MDS-UPDRS total score, groupxtime effect, B = -6.56 [-12.98, -0.13], P < 0.05). Additionally, FMT improved gastrointestinal disorders and a marked increase in the complexity of the microecological system in patients. This study demonstrated that FMT through oral administration is clinically feasible and has the potential to improve the effectiveness of current medications in the clinical symptoms of PD patients.

引用

页数：21

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