Safety of Sotrovimab use in children with COVID-19: an Italian experience

被引：1

作者：

Venturini, Elisabetta ^{[1
]}

Fusani, Lara ^{[1
]}

Vecchio, Andrea Lo ^{[2
]}

Scarano, Sara Maria ^{[2
]}

Garazzino, Silvia ^{[3
]}

Pruccoli, Giulia ^{[3
]}

Dona, Daniele ^{[4
]}

Lancella, Laura ^{[5
]}

Gattinara, Guido Castelli ^{[5
]}

Galli, Luisa ^{[1
,6
,7
]}

机构：

[1] IRCSS Meyer Childrens Univ Hosp, Infect Dis Unit, Florence, Italy

[2] Univ Naples Federico II, Dept Translat Med Sci, Pediat Infect Dis Unit, Naples, Italy

[3] Univ Turin, Regina Margher Childrens Hosp, Dept Pediat & Publ Hlth Sci, Infect Dis Unit, Turin, Italy

[4] Univ Padua, Dept Womens & Childrens Hlth, Div Pediat Infect Dis, Padua, Italy

[5] IRCCS Bambino Gesu Children Hosp, Rome, Italy

[6] Univ Florence, Dept Hlth Sci, Florence, Italy

[7] IRCSS Meyer Childrens Hosp, Infect Dis Unit, Viale Pieraccini 24, Florence, Italy

来源：

JOURNAL OF CHEMOTHERAPY | 2024年 / 36卷 / 01期

关键词：

Sotrovimab; SARS-CoV-2; omicron; monoclonal antibodies; children; covid-19; variant of concern; HIGH-RISK; SARS-COV-2;

D O I：

10.1080/1120009X.2023.2250138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sotrovimab is a monoclonal antibody approved in adult and adolescents at high risk for COVID-19. Thirty-three children evaluated in five Italian paediatric centres received Sotrovimab infusion and were retrospectively enrolled from December 2021 to April 2022. In more than half of cases (19/33, 57.6%) Sotrovimab was prescribed off-label. Overall, the infusion was well tolerated with no significative differences in those receiving an off-label prescription. All children had a complete recovery. Data on the safety of Sotrovimab should be investigated in a larger paediatric cohort, considering the continuous selection of new SARS CoV-2 variants which may be more or less susceptible to the effects of the Sotrovimab.

引用

页码：45 / 48

页数：4

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