Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?

被引:43
作者
Merkin, Ashley [1 ,4 ]
Sghirripa, Sabrina [1 ,2 ,4 ]
Graetz, Lynton [1 ,4 ]
Smith, Ashleigh E. [5 ]
Hordacre, Brenton [6 ]
Harris, Richard [8 ]
Pitcher, Julia [7 ]
Semmler, John [2 ]
Rogasch, Nigel C. [3 ,4 ,9 ,10 ]
Goldsworthy, Mitchell [1 ,2 ,3 ,4 ]
机构
[1] Univ Adelaide, Sch Biomed, Lifespan Human Neurophysiol Grp, Adelaide, Australia
[2] Univ Adelaide, Sch Biomed Discipline Physiol, Adelaide, Australia
[3] Univ Adelaide, Adelaide Med Sch, Discipline Psychiat, Adelaide, Australia
[4] South Australian Hlth & Med Res Inst, Hopwood Ctr Neurobiol, Lifelong Hlth Theme, Adelaide, Australia
[5] Univ South Australia, Alliance Res Exercise Nutr & Act ARENA Res Ctr, Allied Hlth & Human Performance, Adelaide, Australia
[6] Univ South Australia, Innovat Implementat & Clin Translat IIMPACT Hlth, Allied Hlth & Human Performance, Adelaide, Australia
[7] Deakin Univ, Sch Med, Burwood, Australia
[8] Univ Leeds, Sch Psychol, Leeds, England
[9] Monash Univ, Sch Psychol Sci, Brain Mind & Soc Res Hub, Melbourne, Vic, Australia
[10] Monash Univ, Turner Inst Brain & Mental Hlth, Level 7 SAHMRI,North Terrace, Melbourne, Vic 5000, Australia
基金
英国医学研究理事会;
关键词
Electroencephalography; Oscillations; Age; Alpha; Aperiodic; 1; f; BRAIN-WAVE FREQUENCY; ALZHEIMERS-DISEASE; REACTION-TIME; PREFRONTAL CORTEX; CORTICAL RHYTHMS; PEAK FREQUENCY; RESPONSE-TIME; POWER SPECTRA; STATE; OSCILLATIONS;
D O I
10.1016/j.neurobiolaging.2022.09.003
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Alpha-band oscillatory activity in human electroencephalography (EEG) becomes slower and lower in am-plitude with advanced age. However, the influence of aperiodic activity on these measures has received little consideration. We investigated whether age-related differences in aperiodic activity explains differ-ences in resting EEG peak alpha frequency and power. We assessed aperiodic activity in 85 younger and 92 older adults by fitting the 1/f-like background activity evident in EEG power spectra using the spec-tral parameterization ("specparam") algorithm. Across the scalp, the aperiodic exponent and offset were smaller in older compared to younger participants, reflecting a flatter 1/f-like slope and a downward broadband shift in power spectra with age. After correcting for aperiodic activity, peak alpha frequency remained slower in older adults; however, peak alpha power no longer differed statistically between age groups. The large sample size utilized in this study, as well as the depth of analysis, provides further evidence that the aperiodic component of the resting EEG signal is altered with aging and should be considered when investigating neural oscillatory activity.(c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码:78 / 87
页数:10
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