Management of IgE-mediated food allergy in the 21st century

被引:16
|
作者
Cafarotti, Arianna [1 ]
Giovannini, Mattia [2 ]
Begin, Philippe [3 ,4 ]
Brough, Helen A. [5 ,6 ]
Arasi, Stefania [1 ]
机构
[1] Bambino Gesu Pediat Hosp, IRCCS, Allergy Unit, Area Translat Res Pediat Special, Rome, Italy
[2] Meyer Childrens Univ Hosp, Dept Pediat, Allergy Unit, Florence, Italy
[3] CHU St Justine, Dept Pediat, Allergy Immunol & Rheumatol Div, Montreal, PQ, Canada
[4] Ctr Hosp Univ Montreal, Dept Med, Allergy & Clin Immunol Div, Montreal, PQ, Canada
[5] Guys & St Thomas NHS Fdn Hosp, Evelina Childrens Hosp, Childrens Allergy Serv, London, England
[6] Kings Coll London, Paediat Allergy Grp, Dept Women & Childrens Hlth, Sch Life Course Sci, London, England
来源
CLINICAL AND EXPERIMENTAL ALLERGY | 2023年 / 53卷 / 01期
关键词
QUALITY-OF-LIFE; PEANUT ORAL IMMUNOTHERAPY; MILK PROTEIN ALLERGY; COWS MILK; DOUBLE-BLIND; CHILDREN; OMALIZUMAB; DIAGNOSIS; ANAPHYLAXIS; EPINEPHRINE;
D O I
10.1111/cea.14241
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The 21st century has seen the propulsion of research in the field of food allergy, which has driven real changes in the clinical approach. Allergen immunotherapy has been recommended for the active management of food allergy. Data have shown promising additional methods of treatment, including biologics. Efforts have been devoted to the risk stratification of food allergy and the standardization of the assessment of food-allergic severity. Alternative routes of administration of epinephrine are under investigation to minimize any mechanical issue and the fear of injections. Evidence-based guidelines have been published by the main international societies in the field of anaphylaxis and food allergy management and new updates are in preparation. In the coming years, treatment options that are currently in pre-clinical or early clinical evaluation will hopefully lead to safe and effective disease-modifying therapies for food allergy in clinical practice. The identification of reliable biomarkers and the standardization of definitions and measurement approaches, alongside a shared decision-making with patients and families, will be key for the development of personalized care and to help minimize the substantial burden of food allergy.
引用
收藏
页码:25 / 38
页数:14
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