Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

被引：22

作者：

Zeidan, Nancy M. S. ^{[1
]}

El Lateef, Hanan M. Abd ^{[2
]}

Selim, Dalia M. ^{[2
]}

Razek, Suzan A. ^{[2
]}

Abd-Elrehim, Ghada A. B. ^{[3
]}

Nashat, Mohamed ^{[4
]}

ElGyar, Noha ^{[5
]}

Waked, Nevin M. ^{[6
]}

Soliman, Attia A. ^{[7
]}

Elhewala, Ahmed A. ^{[7
]}

Shehab, Mohamed M. M. ^{[7
]}

Ibraheem, Ahmed A. A. ^{[7
]}

Shehata, Hassan ^{[7
]}

Yousif, M. Yousif ^{[7
]}

Akeel, Nagwa E. ^{[7
]}

Hashem, Mustafa I. A. ^{[7
]}

Ahmed, Amani A. ^{[7
]}

Emam, Ahmed A. ^{[7
]}

Abdelmohsen, Mohamed M. ^{[8
]}

Ahmed, Mohamed F. ^{[8
]}

Saleh, Ahmed S. E. ^{[9
]}

Eltrawy, Heba H. ^{[10
]}

Shahin, Gehan H. ^{[11
]}

Nabil, Rehab M. ^{[12
]}

Hosny, Thoraya A. ^{[12
]}

Abdelhamed, Mohamed R. ^{[13
]}

Afify, Mona R. ^{[14
]}

Alharbi, Mohanned T. ^{[14
]}

Nagshabandi, Mohammed K. ^{[14
]}

Tarabulsi, Muyassar K. ^{[14
]}

Osman, Sherif F. ^{[15
]}

Abd-Elrazek, Amal S. M. ^{[16
]}

Rashad, Manal M. ^{[17
]}

El-Gaaly, Sonya A. A. ^{[18
]}

Gad, Said A. B. ^{[19
]}

Mohamed, Y. Mohamed ^{[20
]}

Abdelkhalek, Khalil ^{[1
]}

Yousef, Aly A. ^{[21
]}

机构：

[1] Cairo Univ, Fac Med, Dept Pediat, Giza, Egypt

[2] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt

[3] Sohag Univ, Fac Med, Dept Pediat, Sohag, Sohag, Egypt

[4] Aswan Univ, Fac Med, Dept Pediat, Aswan, Aswan, Egypt

[5] Assiut Univ, Fac Med, Dept Pediat, Assiut, Egypt

[6] October 6 Univ, Fac Med, Dept Pediat, 6th Of October City, Egypt

[7] Zagazig Univ, Fac Med, Dept Pediat, Zagazig, Egypt

[8] Al Azhar Univ, Fac Med Boys, Dept Pediat, Cairo, Egypt

[9] Benha Univ, Fac Med, Dept Otorhinolaryngol, Banha, Egypt

[10] Al Azhar Univ, Fac Med Girls, Dept Chest Dis, Cairo, Egypt

[11] Cairo Univ, Fac Med, Dept Clin Pathol, Giza, Giza, Egypt

[12] Zagazig Univ, Fac Med, Dept Clin Pathol, Zagazig, Egypt

[13] Al Azhar Fac Med, Dept Clin Pathol, Cairo, Egypt

[14] Univ Jeddah, Fac Med, Dept Med MicroBiol & Parasitol, Jeddah, Saudi Arabia

[15] Texas Tech Univ, Dept Radiol, Hlth Scie Ctr, El Paso, TX USA

[16] Menoufia Univ, Dept Radio Diag, Shibin Al Kawm, Egypt

[17] Zagazig Univ, Fac Med, Dept Anesthesia, Zagazig, Egypt

[18] Ain Shams Univ, Fac Med, Dept Internal Med, Cairo, Egypt

[19] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt

[20] Ain Shams Univ, Fac Med, Dept Psychiat, Cairo, Egypt

[21] Helwan Univ, Fac Med, Dept Pediat, Helwan, Egypt

来源：

PEDIATRIC RESEARCH | 2023年 / 93卷 / 05期

关键词：

GENE; PNEUMONIA; VDR; TRANSCRIPTION; ASSOCIATIONS; CHILDREN; BLOCKING;

D O I：

10.1038/s41390-022-02275-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BACKGROUND: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility. METHODS: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL. RESULTS: Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96-4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95-8.55]; P < 0.001). CONCLUSIONS: Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents.

引用

页码：1383 / 1390

页数：8

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