A novel oxoisoaporphine-type alkaloid from the rhizome of Menispermum dauricum

被引：1
作者：
Ren, Wen-Jing [1 ,2 ]
Zhu, Guo-Yuan [2 ]
Ma, Yan [1 ]
Cao, Yan-Hua [3 ]
Duan, Bao-Guo [4 ]
Liu, Yu-Hong [1 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Sch Pharmaceut Sci, Jinan 250355, Peoples R China
[2] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
[3] Shandong First Med Univ, Dept Pharm, Shandong Prov Hosp, Jinan 250021, Peoples R China
[4] Sishui Siheyuan Culture & Tourism Dev Co Ltd, Sisui 273200, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Menispermaceae; Menispermum dauricum; alkaloids; oxoisoaporphine-type; aporphine-type; cytotoxicity; CHEMICAL-CONSTITUENTS;
D O I：
10.1080/10286020.2022.2050706
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A phytochemical investigation of Menispermum dauricum led to the isolation of five oxoisoaporphine-type alkaloids (1-5) and five aporphine-type alkaloids (6-10), including a novel oxoisoaporphine-type alkaloid: menispeimin A (1). Their structures were elucidated by spectroscopic studies including MS, 1 D and 2 D NMR, and confirmed by comparing with literature data. Among them, alkaloids 4-10 were obtained for the first time from Menispermum genus. Natural products 2, 4 and 6 exhibited significant cytotoxic activity against A549, Bel-7402 and MCF-7 cell lines.
引用
收藏
页码：95 / 101
页数：7
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