A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus

被引：0

作者：

Diamond, Michael S. ^{[1
]}

Boon, Adrianus C. M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63130 USA

来源：

NATURE IMMUNOLOGY | 2024年 / 25卷 / 3期

关键词：

D O I：

10.1038/s41590-024-01744-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When nasally delivered in mice and hamsters, the vaccine stimulated mucosal antibody production and CD8(+) T cell responses, and demonstrated protection against several SARS-CoV-2 strains, including the antigenically distant Omicron XBB.1.5 strain. Immune cell depletion studies showed that cross-reactive memory CD8(+) T cells contribute to the cross-protection that is conferred by nasal vaccines against respiratory infection with antigenically shifted SARS-CoV-2 Omicron strains.

引用

页码：401 / 402

页数：2

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