A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus

被引：0
作者：
Diamond, Michael S. [1 ]
Boon, Adrianus C. M. [1 ]
机构：
[1] Washington Univ, Sch Med, St Louis, MO 63130 USA
来源：
NATURE IMMUNOLOGY | 2024年 / 25卷 / 3期
关键词：
D O I：
10.1038/s41590-024-01744-w
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When nasally delivered in mice and hamsters, the vaccine stimulated mucosal antibody production and CD8(+) T cell responses, and demonstrated protection against several SARS-CoV-2 strains, including the antigenically distant Omicron XBB.1.5 strain. Immune cell depletion studies showed that cross-reactive memory CD8(+) T cells contribute to the cross-protection that is conferred by nasal vaccines against respiratory infection with antigenically shifted SARS-CoV-2 Omicron strains.
引用
收藏
页码：401 / 402
页数：2
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