Targeting Autophagy in Atrial Fibrillation

被引：1
作者：
Ye, Qiang [1 ]
Chen, Wen [1 ]
Fu, Hengsong [1 ]
Ding, Yanling [1 ]
Jing, Yuling [1 ]
Shen, Jingsong [1 ]
Yuan, Ziyang [1 ]
Zha, Kelan [1 ]
机构：
[1] Southwest Med Univ, Dept Cardiol, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China
来源：
REVIEWS IN CARDIOVASCULAR MEDICINE | 2023年 / 24卷 / 10期
关键词：
atrial anatomical remodeling; atrial electrical remodeling; atrial fibrillation; autophagy; energy metabolism remodeling; DOWN-REGULATION; PROTEIN-KINASE; ACTIVATION; DEGRADATION; INHIBITION; HEART; PATHOPHYSIOLOGY; PROTEOSTASIS; DYSFUNCTION; MECHANISM;
D O I：
10.31083/j.rcm2410288
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) is the most common type of arrhythmia in clinical practice, and its incidence is positively correlated with risk factors that include advanced age, hypertension, diabetes, and heart failure. Although our understanding of the mechanisms that govern the occurrence and persistence of AF has been increasing rapidly, the exact mechanism of AF is still not fully understood. Autophagy is an evolutionarily highly conserved and specific physiological process in cells that has been suggested as a potential therapeutic target for several cardiovascular diseases including the pathophysiology of AF. The present article provides an updated review of the fastprogressing field of research surrounding autophagy in AF, and how regulating autophagy might be a therapeutic target to reduce the incidence of AF.
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页数：12
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