bacterial life cycle;
binary and nonbinary division;
chromosome organization;
initiation of chromosome replication;
oriC;
choreography of chromosome replication;
NUCLEOID-ASSOCIATED PROTEINS;
CELL-CYCLE;
GENOME SEQUENCE;
DIVISION;
PREY;
STREPTOMYCES;
ORGANIZATION;
SEGREGATION;
RECOGNITION;
SPORULATION;
D O I:
10.1093/femsre/fuad057
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Bdellovibrio bacteriovorus, an obligate predatory Gram-negative bacterium that proliferates inside and kills other Gram-negative bacteria, was discovered more than 60 years ago. However, we have only recently begun to understand the detailed cell biology of this proficient bacterial killer. Bdellovibrio bacteriovorus exhibits a peculiar life cycle and bimodal proliferation, and thus represents an attractive model for studying novel aspects of bacterial cell biology. The life cycle of B. bacteriovorus consists of two phases: a free-living nonreplicative attack phase and an intracellular reproductive phase. During the reproductive phase, B. bacteriovorus grows as an elongated cell and undergoes binary or nonbinary fission, depending on the prey size. In this review, we discuss: (1) how the chromosome structure of B. bacteriovorus is remodeled during its life cycle; (2) how its chromosome replication dynamics depends on the proliferation mode; (3) how the initiation of chromosome replication is controlled during the life cycle, and (4) how chromosome replication is spatiotemporally coordinated with the proliferation program. A predatory bacterium, Bdellovibrio bacteriovorus possesses a tightly packed chromosome and exhibits a unique "asynchronous mode" of replication (re)initiation.
机构:
Rutgers New Jersey Med Sch, Dept Med, Newark, NJ 07101 USA
Rutgers New Jersey Med Sch, Ctr Emerging Pathogens, Newark, NJ 07101 USA
Rutgers New Jersey Med Sch, Mol Resource Facil, Newark, NJ 07101 USARutgers Sch Dent Med, Dept Oral Biol, Newark, NJ 07101 USA
Lemenze, Alexander
Donnelly, Robert J.
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机构:
Rutgers New Jersey Med Sch, Mol Resource Facil, Newark, NJ 07101 USARutgers Sch Dent Med, Dept Oral Biol, Newark, NJ 07101 USA
Donnelly, Robert J.
Connell, Nancy D.
论文数: 0引用数: 0
h-index: 0
机构:
Rutgers New Jersey Med Sch, Dept Med, Newark, NJ 07101 USA
Rutgers New Jersey Med Sch, Ctr Emerging Pathogens, Newark, NJ 07101 USARutgers Sch Dent Med, Dept Oral Biol, Newark, NJ 07101 USA