Curculigoside Inhibits the Progression of Osteoarthritis via Regulating Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3

被引：0

作者：

Shen, Guowei ^{[1
]}

Yan, Shichang ^{[1
]}

Shen, Siyuan ^{[1
]}

Liang, Feng ^{[1
]}

Xiao, Shouyun ^{[1
]}

Zhang, Yunpeng ^{[1
]}

Zhang, Yongtao ^{[2
]}

Ding, Huimin ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated BenQ Hosp, BenQ Med Ctr, Dept Orthoped, Nanjing 210019, Jiangsu, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Orthoped, Qingdao 266000, Shandong, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2023年 / 19卷 / 09期

关键词：

Curculigoside; Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3; Osteoarthritis; Inflammation; GENE-EXPRESSION; INFLAMMASOME; ACTIVATION; DIFFERENTIATION; PROMOTES; COLLAGEN; CELLS;

D O I：

10.1166/jbn.2023.3695

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This study aimed to explore the potential effects of curculigoside on NLRP3 expression and catabolic genes in osteoarthritis (OA) development. OA mouse models were generated by destabilizing the medial meniscus (DMM) and treated with curculigoside. Curculigoside treatment resulted in dose-dependent reductions in OARSI scores, with the 20 mu g dose restoring scores to normal levels. Curculigoside increased mRNA and protein levels of iNOS and MMP9 induced by DMM surgery in a dose-dependent manner. Moreover, curculigoside downregulated the expression of NLRP3, NF-KB, and PKR at both mRNA and protein levels. Additionally, curculigoside reversed the effects of IL-1/3 on MMP-9, iNOS, and Col2A mRNA and protein levels in a IP:dose-dependent 203.8.109.20manner, On: similarTue,to 10the Oct NLRP32023 inhibitor12:14:42MCC950. In vivo and in vitro results supported curculigoside's potential to aid cartilage restortion in OA patientby blocking the NLRP3 pathway. These Copyright: American Scientif c Publis he s findings suggest curculigoside as a potential therapeutic option for OA, offering hope for improved public health outcomes Delivered by Inge ta related to this degenerative joint condition.

引用

页码：1594 / 1602

页数：9

共 32 条

[1] Pro-inflammatory cytokines and structural biomarkers are effective to categorize osteoarthritis phenotype and progression in Standardbred racehorses over five years of racing career [J].