Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study

被引：4

作者：

Matsuo, Ryotaro ^{[1
,2
]}

Ikeda, Ai ^{[1
,3
,4
]}

Tomooka, Kiyohide ^{[4
]}

Naito, Yoshihiko ^{[5
]}

Uesugi, Yuichi ^{[5
,6
]}

Maruyama, Koutatsu ^{[7
]}

Kawamura, Ryoichi ^{[8
]}

Takata, Yasunori ^{[8
]}

Osawa, Haruhiko ^{[8
]}

Saito, Isao ^{[9
]}

Tanigawa, Takeshi ^{[1
,10
]}

机构：

[1] Juntendo Univ, Grad Sch Med, Dept Publ Hlth, Tokyo, Japan

[2] Juntendo Univ, Dept Cardiovasc Biol & Med, Grad Sch Med, Tokyo, Japan

[3] Juntendo Univ, Fac Int Liberal Arts, Tokyo, Japan

[4] Juntendo Univ, Dept Publ Hlth, Fac Med, Tokyo, Japan

[5] Mukogawa Womens Univ, Sch Food Sci & Nutr, Dept Food Sci & Nutr, Nishinomiya, Hyogo, Japan

[6] Kyoto Coll Nutr & Med Sci, Kyoto, Japan

[7] Ehime Univ, Grad Sch Agr, Special Course Food & Hlth Sci, Lab Community Hlth & Nutr,Dept Biosci, Matsuyama, Ehime, Japan

[8] Ehime Univ, Grad Sch Med, Dept Diabet & Mol Genet, Matsuyama, Ehime, Japan

[9] Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, Oita, Japan

[10] Juntendo Univ, Dept Publ Hlth, Grad Sch Med, 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2024年 / 31卷 / 02期

关键词：

Physical activity; Arterial stiffness; Cardiovascular disease; Cardio-ankle vascular index; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; INDEX CAVI; RISK; EXERCISE; ADULTS; MECHANISMS; MORTALITY; SEDENTARY;

D O I：

10.5551/jat.64173

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aims: Several studies have revealed an association between moderate-to-vigorous physical activity (MVPA) and arterial stiffness, which is a known risk factor for cardiovascular disease. However, a few studies have considered the difference in the longitudinal effect of its intensity in a large general population. Therefore, we examined the effect of MVPA intensity on longitudinal changes in arterial stiffness.Methods: We conducted a prospective cohort study involving 1,982 Japanese men and women. Arterial stiffness was measured using the cardio-ankle vascular index (CAVI) at baseline and 5-year follow-up. Physical activity was quantified using the Japan Arteriosclerosis Longitudinal Study Physical Activity Questionnaire and categorized into quartiles as MVPA levels. Linear mixed models were used to examine the differences at baseline and the rate of changes in CAVI associated with MVPA levels for over 5 years.Results: The multivariable-adjusted mean differences in CAVI at baseline were significantly lower in the third (& beta; = -0.019 [95% confidence interval {CI}=-0.033 to -0.005]) and fourth (& beta;= -0.018 [95% CI=-0.035 to -0.001]) quartiles of the MVPA group compared with those in the lowest quartile of MVPA, and the significant effect persisted 5 years later.Conclusions: In summary, this study provides evidence to support the existence of a threshold for beneficial levels of MVPA in the prevention of arterial stiffness. Furthermore, this study suggests that exceeding this threshold may exert similar effects on arterial stiffness. These findings suggest that an optimal level of MVPA exists for preventing arterial stiffness, and exceeding this threshold may not engender additional benefits.

引用

页码：171 / 179

页数：9