Synthesis and Biological Properties of N-Acylaminoacryloylhistamines and the Corresponding 4-Arylideneimidazol-5(4H)-ones

被引：0

作者：

Topuzyan, V. O. ^{[1
]}

Hovhannisyan, A. A. ^{[1
]}

Tosunyan, S. R. ^{[1
]}

Makichyan, A. T. ^{[1
,2
]}

Hovhannisyan, N. A. ^{[1
]}

Shahkhatuni, A. A. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

[2] Russian Armenian Univ, Yerevan 0051, Armenia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 06期

关键词：

histamine; alpha; beta-dehydroamino acid amides; 4-arylidenoxazol-5(4H)-ones; 4-arylidenimidazol-5(4H)-ones; CARBONIC-ANHYDRASE ACTIVATORS; AFFINITY ISOZYMES I; DERIVATIVES; ANTICHOLINESTERASE; SOFTWARE;

D O I：

10.1134/S1070363223060051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of unsaturated 4-arylidenoxazol-5(4H)-ones with 2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride was used to synthesize histamine N-acyl derivatives containing alpha,beta-dehydroamino acids residues, as well as the corresponding 4-arylidenimidazol-5(4H)-ones. Anticholinesterase and antiradical properties of the synthesized compounds were studied. It was revealed that the studied substances have anticholinesterase activity both acetylcholinesterase and butyrylcholinesterase and have almost no antiradical activity.

引用

页码：1352 / 1359

页数：8

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