Genome-wide mutation profiles from cell-free DNA for early cancer detection

被引：1

作者：

Bruhm, Daniel C. ^{[1
]}

Velculescu, Victor E. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

NATURE GENETICS | 2023年 / 55卷 / 08期

关键词：

D O I：

10.1038/s41588-023-01448-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Through whole-genome sequencing of single molecules of circulating cell-free DNA, we found that tumor-derived mutations in cancer genomes are associated with regions of late replication timing and other chromatin features. These genome-wide analyses identified altered regional mutation profiles in people with cancer that distinguished them from people without cancer and reflected tumor burden during therapy.

引用

页码：1261 / 1262

页数：2

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