Transmission of SARS-CoV-2 from mother to fetus or neonate: What to know and what to do?

被引：16
作者：
De Luca, Daniele [1 ,4 ]
Vauloup-Fellous, Christelle [2 ]
Benachi, Alexandra [3 ]
Vivanti, Alexandre [3 ]
机构：
[1] Paris Saclay Univ Hosp, APHP, Antoine Beclere Hosp, Div Pediat & Neonatal Crit Care, Clamart, France
[2] Paris Saclay Univ Hosp, APHP, Paul Brousse Hosp, Div Virol, Villejuif, France
[3] Paris Saclay Univ Hosp, APHP, Antoine Beclere Hosp, Div Obstet & Gynecol, Clamart, France
[4] Hop Antoine Beclere, Div Pediat & Neonatal Crit Care, 157 rue porte Trivaux, F-92140 Clamart, France
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2023年 / 28卷 / 01期
关键词：
COVID-19; Pregnancy; Infant; Vertical; Infection; Stillbirth; NICU; SYNDROME CORONAVIRUS 2; SEPTIC SHOCK; INFECTION; COVID-19; PREGNANCY; PLACENTA; OUTCOMES; TMPRSS2; ACE2; BARRIER;
D O I：
10.1016/j.siny.2023.101429
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
SARS-CoV-2 can be vertically transmitted from the mother to the fetus and the neonate. This transmission route is rare compared to the environmental or horizontal spread and therefore, the risk can be deemed inconse-quential by some medical providers. However, severe, although just as rare, feto-neonatal consequences are possible: fetal demise, severe/critical neonatal COVID-19 and multi-inflammatory syndrome (MIS-N) have been described. Therefore, it is important for the clinicians to know the mechanism of vertical transmission, how to recognize this, and how to deal with neonatal COVID-19 and MIS-N. Our knowledge about this field has significantly increased in the last three years. This is a summary of the pathophysiology, diagnostics, and therapeutics of vertical SARS-CoV-2 transmission that clinicians apply in their clinical practice.
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页数：10
相关论文
共 106 条
[51]   Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review [J].
Juan, J. ;
Gil, M. M. ;
Rong, Z. ;
Zhang, Y. ;
Yang, H. ;
Poon, L. C. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2020, 56 (01) :15-27
[52]   Presence of SARS-CoV-2 in the lower genital tract of women with active COVID-19 infection: A prospective study [J].
Khoiwal, Kavita ;
Kalita, Deepjyoti ;
Kumari, Reena ;
Dhundi, Deepika ;
Shankar, Ravi ;
Kumari, Ranjeeta ;
Gaurav, Amrita ;
Bahadur, Anupama ;
Panda, Prasan Kumar ;
Tomy, Akhil ;
Chaturvedi, Jaya .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2022, 157 (03) :744-747
[53]  
Kienast P, 2023, LANCET REG HEALTH-EU, V21
[54]   Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC) [J].
Kneyber, Martin C. J. ;
de Luca, Daniele ;
Calderini, Edoardo ;
Jarreau, Pierre-Henri ;
Javouhey, Etienne ;
Lopez-Herce, Jesus ;
Hammer, Jurg ;
Macrae, Duncan ;
Markhorst, Dick G. ;
Medina, Alberto ;
Pons-Odena, Marti ;
Racca, Fabrizio ;
Wolf, Gerhard ;
Biban, Paolo ;
Brierley, Joe ;
Rimensberger, Peter C. .
INTENSIVE CARE MEDICINE, 2017, 43 (12) :1764-1780
[55]   Placental barrier against COVID-19 [J].
Komine-Aizawa, Shihoko ;
Takada, Kazuhide ;
Hayakawa, Satoshi .
PLACENTA, 2020, 99 :45-49
[56]   Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis [J].
Kotlyar, Alexander M. ;
Grechukhina, Olga ;
Chen, Alice ;
Popkhadze, Shota ;
Grimshaw, Alyssa ;
Tal, Oded ;
Taylor, Hugh S. ;
Tal, Reshef .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021, 224 (01) :35-+
[57]   Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019 [J].
Li, Diangeng ;
Jin, Meiling ;
Bao, Pengtao ;
Zhao, Weiguo ;
Zhang, Shixi .
JAMA NETWORK OPEN, 2020, 3 (05) :e208292
[58]   The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study [J].
Li, Mengmeng ;
Chen, Liang ;
Zhang, Jingxiao ;
Xiong, Chenglong ;
Li, Xiangjie .
PLOS ONE, 2020, 15 (04)
[59]   SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes [J].
Li, Yijia ;
Schneider, Alexis M. ;
Mehta, Arnav ;
Sade-Feldman, Moshe ;
Kays, Kyle R. ;
Gentili, Matteo ;
Charland, Nicole C. ;
Gonye, Anna L. K. ;
Gushterova, Irena ;
Khanna, Hargun K. ;
LaSalle, Thomas J. ;
Lavin-Parsons, Kendall M. ;
Lilley, Brendan M. ;
Lodenstein, Carl L. ;
Manakongtreecheep, Kasidet ;
Margolin, Justin D. ;
McKaig, Brenna N. ;
Parry, Blair A. ;
Rojas-Lopez, Maricarmen ;
Russo, Brian C. ;
Sharma, Nihaarika ;
Tantivit, Jessica ;
Thomas, Molly F. ;
Regan, James ;
Flynn, James P. ;
Villani, Alexandra-Chloe ;
Hacohen, Nir ;
Goldberg, Marcia B. ;
Filbin, Michael R. ;
Li, Jonathan Z. .
JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (13)
[60]   Evaluation of the presence of SARS-CoV-2 in vaginal and anal swabs of women with omicron variants of SARS-CoV-2 infection [J].
Liu, Ding ;
Zhang, Yunfu ;
Chen, Dongfeng ;
Wang, Xianhua ;
Huang, Fuling ;
Long, Ling ;
Zheng, Xiuhui .
FRONTIERS IN MICROBIOLOGY, 2022, 13
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