Transmission of SARS-CoV-2 from mother to fetus or neonate: What to know and what to do?

被引：16

作者：

De Luca, Daniele ^{[1
,4
]}

Vauloup-Fellous, Christelle ^{[2
]}

Benachi, Alexandra ^{[3
]}

Vivanti, Alexandre ^{[3
]}

机构：

[1] Paris Saclay Univ Hosp, APHP, Antoine Beclere Hosp, Div Pediat & Neonatal Crit Care, Clamart, France

[2] Paris Saclay Univ Hosp, APHP, Paul Brousse Hosp, Div Virol, Villejuif, France

[3] Paris Saclay Univ Hosp, APHP, Antoine Beclere Hosp, Div Obstet & Gynecol, Clamart, France

[4] Hop Antoine Beclere, Div Pediat & Neonatal Crit Care, 157 rue porte Trivaux, F-92140 Clamart, France

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2023年 / 28卷 / 01期

关键词：

COVID-19; Pregnancy; Infant; Vertical; Infection; Stillbirth; NICU; SYNDROME CORONAVIRUS 2; SEPTIC SHOCK; INFECTION; COVID-19; PREGNANCY; PLACENTA; OUTCOMES; TMPRSS2; ACE2; BARRIER;

D O I：

10.1016/j.siny.2023.101429

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

SARS-CoV-2 can be vertically transmitted from the mother to the fetus and the neonate. This transmission route is rare compared to the environmental or horizontal spread and therefore, the risk can be deemed inconse-quential by some medical providers. However, severe, although just as rare, feto-neonatal consequences are possible: fetal demise, severe/critical neonatal COVID-19 and multi-inflammatory syndrome (MIS-N) have been described. Therefore, it is important for the clinicians to know the mechanism of vertical transmission, how to recognize this, and how to deal with neonatal COVID-19 and MIS-N. Our knowledge about this field has significantly increased in the last three years. This is a summary of the pathophysiology, diagnostics, and therapeutics of vertical SARS-CoV-2 transmission that clinicians apply in their clinical practice.

引用

页数：10

共 106 条

[1] Committee Opinion No. 797: Prevention of Group B Streptococcal Early-Onset Disease in Newborns (vol 135, pg e51, 2020) [J].

OBSTETRICS AND GYNECOLOGY, 2020, 135 (04) :978-979

[2] COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance [J].

Adhikari, Emily H. ;

MacDonald, Lorre ;

SoRelle, Jeffrey A. ;

Morse, Jessica ;

Pruszynski, Jessica ;

Spong, Catherine Y. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (15) :1500-1502

[3] Detection of severe acute respiratory syndrome corona virus 2 in cervico-vaginal secretion of COVID-19-affected female: A prospective observational study from India [J].

Agarwal, Mukta ;

Basumatary, Swmkwr ;

Bhusan, Divendu ;

Pati, Binod Kumar .

SAGE OPEN MEDICINE, 2021, 9

[4]

Alcover N, 2023, AM J OBSTET GYNECOL, DOI [10.1016/j.ajog.2023.01.019.S0002-9378(23)00026-1, DOI 10.1016/J.AJOG.2023.01.019.S0002-9378(23)00026-1]

[5] Infants prenatally exposed to SARS-CoV-2 show the absence of fidgety movements and are at higher risk for neurological disorders: A comparative study [J].

Aldrete-Cortez, Vania ;

Bobadilla, Liliana ;

Tafoya, Silvia A. ;

Gonzalez-Carpinteiro, Aline ;

Nava, Fernanda ;

Vinals, Carlos ;

Alvarado, Elsa ;

Mendizabal-Espinosa, Rosa ;

Eugenia Gomez-Lopez, Maria ;

Ramirez-Garcia, Luz A. ;

Perez-Miguel, Alejandro .

PLOS ONE, 2022, 17 (05)

[6] Visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy [J].

Algarroba, Gabriela N. ;

Rekawek, Patricia ;

Vahanian, Sevan A. ;

Khullar, Poonam ;

Palaia, Thomas ;

Peltier, Morgan R. ;

Chavez, Martin R. ;

Vintzileos, Anthony M. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 223 (02) :275-278

[7] SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis [J].

Allotey, John ;

Chatterjee, Shaunak ;

Kew, Tania ;

Gaetano, Andrea ;

Stallings, Elena ;

Fernandez-Garcia, Silvia ;

Yap, Magnus ;

Sheikh, Jameela ;

Lawson, Heidi ;

Coomar, Dyuti ;

Dixit, Anushka ;

Zhou, Dengyi ;

Balaji, Rishab ;

Littmoden, Megan ;

King, Yasmin ;

Debenham, Luke ;

Llavall, Anna Clave ;

Ansari, Kehkashan ;

Sandhu, Gurimaan ;

Banjoko, Adeolu ;

Walker, Kate ;

O'Donoghue, Keelin ;

van Wely, Madelon ;

van Leeuwen, Elizabeth ;

Kostova, Elena ;

Kunst, Heinke ;

Khalil, Asma ;

Brizuela, Vanessa ;

Broutet, Nathalie ;

Kara, Edna ;

Kim, Caron Rahn ;

Thorson, Anna ;

Oladapo, Olufemi T. ;

Zamora, Javier ;

Bonet, Mercedes ;

Mofenson, Lynne ;

Thangaratinam, Shakila .

BMJ-BRITISH MEDICAL JOURNAL, 2022, 376

[8] Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts [J].

Angelidou, Asimenia ;

Sullivan, Katherine ;

Melvin, Patrice R. ;

Shui, Jessica E. ;

Goldfarb, Ilona Telefus ;

Bartolome, Ruby ;

Chaudhary, Neha ;

Vaidya, Ruben ;

Culic, Ivana ;

Singh, Rachana ;

Yanni, Diana ;

Patrizi, Silvia ;

Hudak, Mark L. ;

Parker, Margaret G. ;

Belfort, Mandy B. .

JAMA NETWORK OPEN, 2021, 4 (04)

[9] Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2 [J].

Ashary, Nancy ;

Bhide, Anshul ;

Chakraborty, Priyanka ;

Colaco, Stacy ;

Mishra, Anuradha ;

Chhabria, Karisma ;

Jolly, Mohit Kumar ;

Modi, Deepak .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8

[10] Investigation of vaginal and rectal swabs of women infected with COVID-19 in two hospitals covered by Mazandaran University of Medical Sciences, 2020 [J].

Atarod, Zoleikha ;

Zamaniyan, Marzieh ;

Moosazadeh, Mahmood ;

Valadan, Reza ;

Soleimanirad, Seyed Mohsen ;

Gordani, Noushin .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2022, 42 (06) :2225-2229

← 1 2 3 4 5 6 7 8 9 10 →