Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms

被引：43

作者：

Deng, Rou ^{[1
]}

Wang, Fang ^{[1
]}

Wang, Luanfeng ^{[1
]}

Xiong, Ling ^{[1
]}

Song, Haizhao ^{[1
]}

Shen, Xinchun ^{[1
]}

机构：

[1] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Key Lab Grains & Oils Qual Control & Proc, Nanjing 210023, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2023年 / 71卷 / 19期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

polysaccharides; antiaging effects; structure-activity relationships; signaling mechanisms; MOLECULAR-WEIGHT HYALURONAN; LIFE-SPAN; OXIDATIVE STRESS; ASTRAGALUS POLYSACCHARIDE; IN-VITRO; STRUCTURAL ELUCIDATION; AGING ALTERS; ANTIOXIDANT; ABSORPTION; CHITOSAN;

D O I：

10.1021/acs.jafc.3c00493

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Aging refers to the gradual physiological changes that occur in an organism after reaching adulthood, resulting in senescence and a decline in biological functions, ultimately leading to death. Epidemiological evidence shows that aging is a driving factor in the developing of various diseases, including cardiovascular diseases, neurodegenerative diseases, immune system disorders, cancer, and chronic low-grade inflammation. Natural plant polysaccharides have emerged as crucial food components in delaying the aging process. Therefore, it is essential to continuously investigate plant polysaccharides as potential sources of new pharmaceuticals for aging. Modern pharmacological research indicates that plant polysaccharides can exert antiaging effects by scavenging free radicals, increasing telomerase activity, regulating apoptosis, enhancing immunity, inhibiting glycosylation, improving mitochondrial dysfunction regulating gene expression, activating autophagy, and modulating gut microbiota. Moreover, the antiaging activity of plant polysaccharides is mediated by one or more signaling pathways, including IIS, mTOR, Nrf2, NF -KB, Sirtuin, p53, MAPK, and UPR signaling pathways. This review summarizes the antiaging properties of plant polysaccharides and signaling pathways participating in the polysaccharide-regulating aging process. Finally, we discuss the structure-activity relationships of antiaging polysaccharides.

引用

页码：7175 / 7191

页数：17

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