Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells

被引：27

作者：

Arias, Consuelo ^{[1
]}

Sepulveda, Paulina ^{[2
]}

Castillo, Rodrigo L. ^{[3
]}

Salazar, Luis A. ^{[4
]}

机构：

[1] Univ San Sebastian, Escuela Kinesiol, Fac Odontol & Ciencias Rehabil, Santiago 7500922, Chile

[2] Univ La Frontera, Fac Med, Dept Ciencias Preclin, Temuco 4811230, Chile

[3] Univ Chile, Fac Med, Dept Med Interna Oriente, Santiago 7500922, Chile

[4] Univ La Frontera, Fac Med, Ctr Mol Biol & Pharmacogenet, Dept Basic Sci, Temuco 4811230, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

neuroinflammation; hypoxia; Th17; HIF-1; alpha; autoimmune diseases; COGNITIVE IMPAIRMENT; AUTOIMMUNE; DISEASE; EXPRESSION; CYTOKINES; DIFFERENTIATION; MECHANISMS; T(H)17; TUMOR; IL-17;

D O I：

10.3390/ijms24043073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is multifactorial, whereby the therapy available has low clinical efficacy. This review propounds the relationship between the deregulation of T helper cells and hypoxia, mainly Th17 and HIF-1 alpha molecular pathways, events that are involved in the occurrence of the neuroinflammation. The clinical expression of neuroinflammation is included in prevalent pathologies such as multiple sclerosis, Guillain-Barre syndrome, and Alzheimer's disease, among others. In addition, therapeutic targets are analyzed in relation to the pathways that induced neuroinflammation.

引用

页数：18

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