The Bm86 Discovery: A Revolution in the Development of Anti-Tick Vaccines

被引:9
作者
Rodriguez-Mallon, Alina [1 ]
机构
[1] Ctr Genet Engn & Biotechnol, Anim Biotechnol Dept, Ave 31 158 & 190,POB 6162, Havana 10600, Cuba
来源
PATHOGENS | 2023年 / 12卷 / 02期
关键词
Bm86; anti-tick vaccines; ectoparasites; ADULT FEMALE TICKS; BOOPHILUS-MICROPLUS POPULATIONS; ANOPHELES-STEPHENSI DIPTERA; CATTLE TICK; ACQUIRED-RESISTANCE; RHIPICEPHALUS-MICROPLUS; IMMUNOLOGICAL CONTROL; PROTECTIVE ANTIGENS; HYALOMMA-DROMEDARII; INDUCED IMMUNITY;
D O I
10.3390/pathogens12020231
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The presence in nature of species with genetic resistance to ticks, or with acquired resistance after repeated tick infestations, has encouraged the scientific community to consider vaccination as an alternative to the unsustainable chemical control of ticks. After numerous attempts to artificially immunize hosts with tick extracts, the purification and characterization of the Bm86 antigen by Willadsen et al. in 1989 constituted a revolutionary step forward in the development of vaccines against ticks. Previously, innovative studies that had used tick gut extracts for the immunization of cattle against Rhipicepahalus microplus (previously named Boophilus microplus) ticks, with amazingly successful results, demonstrated the feasibility of using antigens other than salivary-gland-derived molecules to induce a strong anti-tick immunity. However, the practical application of an anti-tick vaccine required the isolation, identification, and purification of the responsible antigen, which was finally defined as the Bm86 protein. More than thirty years later, the only commercially available anti-tick vaccines are still based on this antigen, and all our current knowledge about the field application of immunological control based on vaccination against ticks has been obtained through the use of these vaccines.
引用
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页数:8
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