Association of Genetic Polymorphisms of TERT with Telomere Length in Coke Oven Emissions-Exposed Workers

被引：0

作者：

Yan, Mengqing ^{[1
,2
]}

Cheng, Shuai ^{[1
,2
]}

Wang, Sihua ^{[3
]}

Duan, Xiaoran ^{[4
]}

Mensah, Acquaye Reuben ^{[1
]}

Li, Lei ^{[5
]}

Zhang, Yuhong ^{[5
]}

Li, Guoyu ^{[5
]}

Zhao, Junfeng ^{[5
]}

Feng, Feifei ^{[6
]}

Zhou, Xiaoshan ^{[1
]}

Wu, Yongjun ^{[6
]}

Yang, Yongli ^{[7
]}

Wang, Wei ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Zhengzhou, Peoples R China

[2] Key Lab Nanomed & Hlth Inspect Zhengzhou, Zhengzhou, Peoples R China

[3] Henan Inst Occupat Med, Dept Occupat Hlth, Zhengzhou, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Natl Engn Lab Internet Med Syst & Applicat, Zhengzhou, Peoples R China

[5] Zhengzhou Inst Occupat Med, Dept Occupat Hlth, Zhengzhou, Peoples R China

[6] Zhengzhou Univ, Coll Publ Hlth, Dept Toxicol, Zhengzhou, Peoples R China

[7] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2023年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Telomere length; Polymorphisms; TERT; POT1; TERF1; POLYCYCLIC AROMATIC-HYDROCARBONS; REVERSE-TRANSCRIPTASE; BINDING-PROTEINS; CANCER; DAMAGE; TRF1; POT1; SUSCEPTIBILITY; EXPRESSION; RISK;

D O I：

10.1080/09603123.2022.2069687

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We explored the association between variations in the telomere maintenance genes and change in telomere length (TL) in workers. The TL of peripheral blood leukocytes from 544 coke oven workers and 238 controls were detected using the Real-time PCR method. Variations in four genes were then detected using the PCR based restriction fragment length polymorphism. The effects of environmental and genetic factors on TL were subsequently analyzed through covariance analysis and a generalized linear model .The TL of subjects with GG genotypes were longer than those with AG genotype in the TERT rs2736098 locus amongst the controls (P = .032). The combined effect of COEs exposure and AG+AA genotypes had a significant effect on TL (P < .001). The interaction between the COEs exposure factor and the rs2736098AG+AA genotypes had a significant effect on the TL (P < .05). The TL in coke oven workers is associated with the interactions between TERT rs2736098 AG+AA and COEs exposure.

引用

页码：1059 / 1069

页数：11

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