Association of Genetic Polymorphisms of TERT with Telomere Length in Coke Oven Emissions-Exposed Workers

被引：0
|
作者：
Yan, Mengqing [1 ,2 ]
Cheng, Shuai [1 ,2 ]
Wang, Sihua [3 ]
Duan, Xiaoran [4 ]
Mensah, Acquaye Reuben [1 ]
Li, Lei [5 ]
Zhang, Yuhong [5 ]
Li, Guoyu [5 ]
Zhao, Junfeng [5 ]
Feng, Feifei [6 ]
Zhou, Xiaoshan [1 ]
Wu, Yongjun [6 ]
Yang, Yongli [7 ]
Wang, Wei [1 ,2 ]
机构：
[1] Zhengzhou Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Zhengzhou, Peoples R China
[2] Key Lab Nanomed & Hlth Inspect Zhengzhou, Zhengzhou, Peoples R China
[3] Henan Inst Occupat Med, Dept Occupat Hlth, Zhengzhou, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Natl Engn Lab Internet Med Syst & Applicat, Zhengzhou, Peoples R China
[5] Zhengzhou Inst Occupat Med, Dept Occupat Hlth, Zhengzhou, Peoples R China
[6] Zhengzhou Univ, Coll Publ Hlth, Dept Toxicol, Zhengzhou, Peoples R China
[7] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2023年 / 33卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Telomere length; Polymorphisms; TERT; POT1; TERF1; POLYCYCLIC AROMATIC-HYDROCARBONS; REVERSE-TRANSCRIPTASE; BINDING-PROTEINS; CANCER; DAMAGE; TRF1; POT1; SUSCEPTIBILITY; EXPRESSION; RISK;
D O I：
10.1080/09603123.2022.2069687
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
We explored the association between variations in the telomere maintenance genes and change in telomere length (TL) in workers. The TL of peripheral blood leukocytes from 544 coke oven workers and 238 controls were detected using the Real-time PCR method. Variations in four genes were then detected using the PCR based restriction fragment length polymorphism. The effects of environmental and genetic factors on TL were subsequently analyzed through covariance analysis and a generalized linear model .The TL of subjects with GG genotypes were longer than those with AG genotype in the TERT rs2736098 locus amongst the controls (P = .032). The combined effect of COEs exposure and AG+AA genotypes had a significant effect on TL (P < .001). The interaction between the COEs exposure factor and the rs2736098AG+AA genotypes had a significant effect on the TL (P < .05). The TL in coke oven workers is associated with the interactions between TERT rs2736098 AG+AA and COEs exposure.
引用
收藏
页码：1059 / 1069
页数：11
相关论文
共 50 条
  • [1] Benchmark dose assessment for coke oven emissions-induced telomere length effects in occupationally exposed workers in China
    Wang, Wei
    Wang, Pengpeng
    Wang, Sihua
    Duan, Xiaoran
    Wang, Tuanwei
    Feng, Xiaolei
    Li, Lei
    Zhang, Yuhong
    Li, Guoyu
    Zhao, Junfeng
    Li, Leike
    Wang, Yanbin
    Yan, Zhen
    Feng, Feifei
    Zhou, Xiaoshan
    Yao, Wu
    Zhang, Yawei
    Yang, Yongli
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 182
  • [2] Relationship between miRNAs polymorphisms and peripheral blood leukocyte DNA telomere length in coke oven workers: A cross-sectional study
    Guo, Zhifeng
    Zou, Kaili
    Li, Xinling
    Duan, Xiaoran
    Fan, Yahui
    Liu, Xiaohua
    Wang, Wei
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022, 95
  • [3] The association between polymorphisms in tankyrase gene and telomere length in omethoate-exposed workers
    Yang, Yongli
    Tan, Jiebing
    Duan, Xiaoran
    Zhang, Hui
    Feng, Xiaolei
    Wang, Tuanwei
    Wang, Pengpeng
    Ding, Mingcui
    Liu, Suxiang
    Li, Lei
    Liang, Haiyong
    Yao, Wu
    Wang, Wei
    Zhou, Xiaoshan
    CHEMOSPHERE, 2020, 238
  • [4] Effects of coke oven emissions and benzo[a]pyrene on blood pressure and electrocardiogram in coke oven workers
    Yang, Kai
    Jiang, Xuejun
    Cheng, Shuqun
    Chen, Chengzhi
    Cao, Xianqing
    Tu, Baijie
    JOURNAL OF OCCUPATIONAL HEALTH, 2017, 59 (01) : 1 - 7
  • [5] Association of genetic polymorphisms of telomere binding proteins with cholinesterase activity in omethoate-exposed workers
    Ding, Mingcui
    Yang, Yongli
    Duan, Xiaoran
    Wang, Sihua
    Feng, Xiaolei
    Wang, Tuanwei
    Wang, Pengpeng
    Liu, Suxiang
    Li, Lei
    Liu, Junling
    Tang, Lixia
    Niu, Xinhua
    Zhang, Yuhong
    Li, Guoyu
    Yao, Wu
    Cui, Liuxin
    Wang, Wei
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 161 : 563 - 568
  • [6] Genetic Variants of the TERT Gene, Telomere Length, and Circulating TERT as Prognostic Markers in Rectal Cancer Patients
    Rampazzo, Enrica
    Cecchin, Erika
    Del Bianco, Paola
    Menin, Chiara
    Spolverato, Gaya
    Giunco, Silvia
    Lonardi, Sara
    Malacrida, Sandro
    De Paoli, Antonino
    Toffoli, Giuseppe
    Pucciarelli, Salvatore
    De Rossi, Anita
    CANCERS, 2020, 12 (11) : 1 - 15
  • [7] Benchmark dose estimation for coke oven emissions based on oxidative damage in Chinese exposed workers
    Zou, Kaili
    Wang, Pengpeng
    Duan, Xiaoran
    Yang, Yongli
    Zhang, Hui
    Wang, Sihua
    Shi, Liuhua
    Wang, Yanbin
    Yao, Wu
    Wang, Wei
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 202
  • [8] Relationship between TERT Polymorphism and Telomere Length in Workers Exposed to Omethoate
    Cheng Shuai
    Liu Bin
    Guo Zhi Feng
    Duan Xiao Ran
    Liu Su Xiang
    Li Lei
    Yao Wu
    Yang Yong Li
    Wang Wei
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2021, 34 (10) : 838 - 841
  • [9] Genetic Variants of the TERT Gene and Telomere Length in Obstructive Sleep Apnea
    Macek, Piotr
    Poreba, Rafal
    Gac, Pawel
    Bogunia-Kubik, Katarzyna
    Dratwa, Marta
    Wieckiewicz, Mieszko
    Wojakowska, Anna
    Michalek-Zrabkowska, Monika
    Mazur, Grzegorz
    Martynowicz, Helena
    BIOMEDICINES, 2022, 10 (11)
  • [10] The Association Between Polymorphisms in Cell-Cycle Genes and Mitochondrial DNA Copy Number in Coke Oven Workers
    Wang, Yuping
    Tan, Jiebing
    Wang, Wei
    Duan, Xiaoran
    Lappe, Brooke
    Shi, Liuhua
    Yang, Yongli
    Shi, Xuezhong
    FRONTIERS IN PUBLIC HEALTH, 2022, 10
12345