Aluminium fumarate biological metal-organic framework as an emerging tool for isolation and detection trace amounts of sulfadiazine in food and water samples

Owing to negative impacts of sulfadiazine (SDZ) as an important group of synthetic antibiotics on public health and ecological systems, it has been a serious concern in recent years. In this research, aluminium fumarate biological metal-organic framework (AlFum Bio-MOF) was synthesized and applied as the best option in terms of extraction performance for detection and quantification of SDZ in a variety of samples. The chemical/structural properties of as-prepared AlFum Bio-MOF were confirmed by spectroscopy techniques. The influence of pH, amount of adsorbent, ultrasonic time (adsorption time (and ionic strength as the main variables in the extraction process were optimized and inspected with central composite design (CCD). Linear dynamic range (LDR), the limit of detection (LOD), and precision value (expressed as relative standard deviation (RSD)) in selected conditions were 20-580, 5.67 ng mL-1, and 3.40 % (n = 3), respectively. The developed method was successfully applied for the determination of SDZ in different water and food samples at two spiked levels with recoveries between 84 and 104 %. Practically, the dispersive micro-solid phase extraction (D mu-SPE) based on AlFum BioMOFs as sorbent could be used to quantify SDZ in complex matrices at trace amounts with acceptable recoveries.