The role of ROS in tumor infiltrating immune cells and cancer immunotherapy

被引：28
作者：
Shah, Rushil [1 ,2 ]
Ibis, Betul [1 ,2 ]
Kashyap, Monisha [1 ,2 ]
Boussiotis, Vassiliki A. [1 ,2 ,3 ,4 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Canc Ctr, Boston, MA 02215 USA
[4] Beth Israel Deaconess Med Ctr, 330 Brookline Ave,Dana 513, Boston, MA 02215 USA
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2024年 / 151卷
关键词：
Reactive oxygen species; Immune cells; cancer microenvironment; cancer immunotherapy; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; SUPPRESSOR-CELLS; MITOCHONDRIAL PRODUCTION; BACTERICIDAL ACTIVITY; ANTIGEN RECEPTOR; COMPLEX-III; T-CELLS;
D O I：
10.1016/j.metabol.2023.155747
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and epigenetic programs and have an indispensable role in cellular function. In immune cells, ROS are mediators of specialized functions such as phagocytosis, antigen presentation, activation, cytolysis, and differentiation. ROS have a fundamental role in the tumor microenvironment (TME) where they are produced by immune cell-intrinsic and -extrinsic mechanisms. ROS can act as a double-edged sword with short exposures leading to activation in various innate and adaptative immune cells, and prolonged exposures, unopposed by redox balancing antioxidants leading to exhaustion, immunosuppression, and unresponsiveness to cancer immunotherapy. Due to its plasticity and impact on the anti-tumor function of immune cells, attempts are currently in process to harness ROS biology with the purpose to improve contemporary strategies of cancer immunotherapy. Here, we provide a short overview how ROS and various antioxidant systems impact on the function of innate and adaptive immune system cells with emphasis on the TME and immune-based therapies for cancer.
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页数：13
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