Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats

被引:0
|
作者
Novaes, Leonardo S. [1 ]
Bueno-de-Camargo, Leticia M. [1 ]
Shigeo-de-Almeida, Amadeu [1 ]
Juliano, Vitor A. L. [1 ]
Goosens, Ki [2 ]
Munhoz, Carolina D. [1 ]
机构
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Pharmacol, BR-05508000 Sao Paulo, Brazil
[2] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
来源
NEUROBIOLOGY OF STRESS | 2024年 / 28卷
基金
巴西圣保罗研究基金会;
关键词
Restraint; Neuroplasticity; Amygdala; Glucocorticoid signaling; Anxiety; Behavior; RESTRAINT STRESS; LOCUS-COERULEUS; ACTIVATION; ENHANCEMENT;
D O I
10.1016/j.ynstr.2023.100587
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Anxiety, a state related to anticipatory fear, can be adaptive in the face of environmental threats or stressors. However, anxiety can also become persistent and manifest as anxiety-and stress-related disorders, such as generalized anxiety or post-traumatic stress disorder (PTSD). In rodents, systemic administration of glucocorti-coids (GCs) or short-term restraint stress induces anxiety-like behaviors and dendritic branching within the basolateral complex of the amygdala (BLA) ten days later. Additionally, increased arousal-related memory retention mediated by elevated GCs requires concomitant noradrenaline (NE) signaling, both acting in the BLA. It is unknown whether GCs and NE play a role in the delayed acute stress-induced effects on behavior and BLA dendritic plasticity. Here, inhibiting corticosterone (CORT) elevation during 2 h of restraint stress prevents stress-induced increases in delayed anxiety-like behavior and BLA dendritic spine density in rats. Also, we show that the delayed acute stress-induced effects on behavior and morphological alterations are critically dependent on genomic glucocorticoid receptor (GR) actions in the BLA. Unlike CORT, the pharmacological enhancement of NE signaling in the BLA was insufficient to drive delayed anxiety-related behavior. Nonetheless, the delayed anxiety-like behavior ten days after acute stress requires NE signaling in the BLA during stress exposure. Therefore, we define the essential roles of two stress-related hormones for the late stress consequences, acting at two separate times: CORT, via GR, immediately during stress, and NE, via beta-adrenoceptors, during the expression of delayed anxiety.
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页数:14
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