3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy

被引：0
|
作者：
Ni, Linyu [1 ,2 ]
Zhang, Wei [1 ,2 ]
Kim, Wonsuk [3 ]
Warchock, Alexus [1 ,3 ]
Bicket, Amanda [1 ]
Wang, Xueding [2 ,4 ]
Moroi, Sayoko e. [5 ]
Argento, Alan [3 ]
Xu, Guan [1 ,2 ]
机构：
[1] Univ Michigan, Dept Biomed Engn, Dept Ophthalmol & Visual Sci, 500 S State St, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Biomed Engn, 500 S State St, Ann Arbor, MI 48109 USA
[3] Univ Michigan Dearborn, Dept Mech Engn, 4901 Evergreen Rd, Dearborn, MI 48128 USA
[4] Univ Michigan, Dept Radiol, 500 S State St, Ann Arbor, MI 48109 USA
[5] Ohio State Univ, Wexner Med Ctr, Havener Eye Inst, Dept Ophthalmol & Visual Sci, Columbus, OH 43210 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2023年 / 14卷 / 12期
基金：
美国国家科学基金会;
关键词：
HUMOR OUTFLOW STRUCTURES;
D O I：
10.1364/BOE.505288
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding aqueous outflow resistance at the level of aqueous veins has been a challenge to the management of glaucoma. This study investigated resolving the anatomies of aqueous veins and the textures of surrounding sclera using photoacoustic microscopy (PAM). A dual wavelength PAM system was established and validated using imaging phantoms, porcine and human globes perfused with an optical contrast agent ex vivo. The system shows lateral resolution of 8.23 mu m and 4.70 mu m at 1200 nm and 532 nm, respectively, and an axial resolution of 27.6 mu m. The system is able to separately distinguish the aqueous veins and the sclera with high contrast in full circumference of the porcine and human globes.(c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
引用
收藏
页码：6291 / 6300
页数：10
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