Enhancement of cryopreservation with intracellularly permeable zwitterionic polymers

被引：4
|
作者：
Yamasaki, Ryota [1 ]
Rajan, Robin [1 ]
Matsumura, Kazuaki [1 ]
机构：
[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, 1-1 Asahidai, Nomi, Ishikawa 9231292, Japan
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 94期
基金：
日本学术振兴会;
关键词：
ANALOGS;
D O I：
10.1039/d3cc04092e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel copolymer containing zwitterionic and methylsulfinyl structures was developed, which enhanced cryoprotective efficacy by enabling intracellular cytoplasmic permeation without relying on mediated endocytosis and diffused out of the cells within approximately 30 min, making it more advantageous than polymeric nanoparticles for the transport of membrane-impermeable cryoprotectants such as trehalose. Intracellular permeation of zwitterionic polymers was shown to improve cell recovery after freezing and thawing.
引用
收藏
页码：14001 / 14004
页数：4
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