The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases

被引：4
|
作者：
Kim, Youngjo [1 ,2 ]
机构：
[1] Soonchunhyang Univ, Dept Integrated Biomed Sci, Cheonan 31151, South Korea
[2] Soonchunhyang Univ, Soonchunhyang Med Biosci, Cheonan 31151, South Korea
来源：
CURRENT OPINION IN CELL BIOLOGY | 2023年 / 85卷
基金：
新加坡国家研究基金会;
关键词：
EXPRESSION; GENE; NEUROPATHOLOGY; PROLIFERATION; ORGANIZATION; INFLAMMATION; SENESCENCE; NETWORKS; GENOME; LEADS;
D O I：
10.1016/j.ceb.2023.102257
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of lamin B1 in human health and aging has attracted increasing attention as mounting evidence reveals its signifi-cance in diverse cellular processes. Both upregulation and downregulation of lamin B1 have been implicated in age -associated organ dysfunctions and various human diseases, including central nervous system disorders. Additionally, lamin B1 levels undergo alterations in cancer cells, and a tumor -specific association exists between lamin B1 abundance and cancer aggressiveness. Investigating the connectivity between lamin B1 abundance and human health is of utmost impor-tance for further research. This review presents recent ad-vancements in understanding lamin B1's role in nuclear lamina function and its implications for human health.
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页数：7
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