Ring Expansion Reactions through Intramolecular Transamidation

被引：5

作者：

Kalinin, Stanislav ^{[1
]}

Sapegin, Alexander ^{[1
]}

机构：

[1] St Petersburg State Univ, Inst Chem, 26 Universitetskii Prospect, St Petersburg 198504, Russia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年

基金：

俄罗斯科学基金会;

关键词：

aminoacyl inclusion; intramolecular transamidation; lactams; medium-sized cycles; ring expansion; ZIP REACTION; REAMIDATION REACTIONS; BETA-LACTAMS; ENLARGEMENT; HETEROCYCLES;

D O I：

10.1002/ejoc.202300754

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic methodologies based on cycle expansion reactions have proven to be highly effective in delivering valuable medium-sized cycles and macrocycles. A primary method of ring expansion relies on intramolecular transamidation reactions. These reactions typically employ N-aminoalkyl and N-aminoacyl derivatives of lactams and their analogues as starting materials, yielding a diverse spectrum of unique nitrogen-containing heterocycles.This Review aims to provide a comprehensive analysis of the research outcomes related to intramolecular transamidation reactions that lead to cycle expansion. This will offer the reader a perspective on the potential applications of such reactions in generating novel and intriguing types of heterocyclic systems. This review summarizes examples of ring expansion reactions through intramolecular transamidation. This synthetic approach allows the preparation of a wide range of nitrogen-containing heterocycles.image

引用

页数：11

共 58 条

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