Prognostic Potential of Thrombocyte Indices, Acute Phase Proteins, Electrolytes and Acid-Base Markers in Canine Parvovirus Infected Dogs With Systemic Inflammatory Response Syndrome

被引:2
作者
Paul, Babul Rudra [1 ]
De, Ujjwal Kumar [1 ,5 ]
Sarkar, Varun Kumar [1 ]
Gandhar, Jitendra Singh [1 ]
Patra, Manas Kumar [2 ]
Singh, Mithilesh Kumar [3 ]
Soni, Srishti [1 ]
Eregowda, Chethan Gollahalli [4 ]
机构
[1] ICAR Indian Vet Res Inst, Div Med, Izatnagar, Uttar Pradesh, India
[2] ICAR Indian Vet Res Inst, Livestock Prod & Management Sect, Izatnagar, Uttar Pradesh, India
[3] ICAR Indian Vet Res Inst, Immunol Sect, Izatnagar, Uttar Pradesh, India
[4] Coll Vet Sci & Anim Husb, Dept Vet Med, Aizawl, Mizoram, India
[5] ICAR Indian Vet Res Inst, Div Med, Izatnagar 243122, Uttar Pradesh, India
关键词
acid-base; canine parvovirus; electrolyte; thrombocyte; prognosis; SIRS; PLATELET DISTRIBUTION WIDTH; C-REACTIVE PROTEIN; ACTIVATION; SEPSIS; COUNT; ASSOCIATION; PUPPIES; VOLUME; DEATH; CATS;
D O I
10.1016/j.tcam.2023.100803
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Dogs with canine parvovirus enteritis (CPVE) that develop systemic inflammatory response syndrome (SIRS) frequently have a poor prognosis. The aim of the study was to assess the prognostic potential of thrombocyte indices, acute phase proteins, electrolytes, and acid-base markers in CPVE puppies with SIRS (CPVE-SIRS+) at admission. A case-controlled, prospective, and observational study was performed on 36 CPVE puppies. Mean concentrations of C-reactive protein (CRP), albumin, thrombocyte count, mean platelet volume (MPV), platelet distribution width (PDW), sodium (Na+), potassium (K+), chloride (Cl-) and ionized calcium (iCa) were measured and strong ion difference 3 (SID3)(,) A(TOT-albumin) and A(TOT-total protein) were determined in CPVE-SIRS+ survivors and nonsurvivors. A prognostic cut-off value for predicting the disease outcome was determined by receiver operating characteristic (ROC) curve analysis. The mean values of MPV, PDW and CRP were significantly higher and the mean values of albumin, Cl- and A(TOT-albumin) were significantly lower in CPVE-SIRS+ nonsurvivor than CPVE-SIRS+ survivor puppies on the day of admission, but the thrombocyte count, Na+, K+, iCa, SID3 and A(TOT- total protein) values did not differ significantly. The positive predictive values (PPVs) for survival using cut-off value of MPV (<= 15.08 fL), PDW (<= 14.85%), CRP (<= 180.7 mg/L), albumin (>= 1.795 g/dL), Cl- (>= 96.00 mmol/L), and A(TOT-albumin) (>= 7.539) were determined as 100%, 100%, 100%, 80%, 100%, and 80%, respectively with better area under ROC curve and sensitivity. Based on sensitivity, specificity, and PPVs from ROC analysis, it is concluded that the determination of Cl- concentration and MPV at admission followed by CRP will serve as the most appropriate biomarkers in predicting the disease outcome of CPVE puppies that develop SIRS.(c) 2023 Elsevier Inc. All rights reserved.
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页数:6
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