Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles

被引：9

作者：

Bartosch, Carla ^{[1
,2
]}

Nadal, Alfons ^{[3
]}

Braga, Ana C. ^{[4
]}

Salerno, Angela ^{[5
]}

Rougemont, Anne-Laure ^{[6
]}

Van Rompuy, Anne-Sophie ^{[7
]}

Fitzgerald, Brendan ^{[8
]}

Joyce, Caroline ^{[9
]}

Allias, Fabienne ^{[10
]}

Maher, Geoffrey J. ^{[11
]}

Turowski, Gitta ^{[12
]}

Tille, Jean-Christophe ^{[6
]}

Alsibai, Kinan Drak ^{[13
,14
]}

van de Vijver, Koen ^{[15
]}

Mcmahon, Lesley ^{[16
]}

Sunde, Lone ^{[17
]}

Pyzlak, Michal ^{[18
]}

Downey, Paul ^{[19
]}

Wessman, Sandra ^{[20
]}

Patrier, Sophie ^{[21
]}

Kaur, Baljeet ^{[22
]}

Fisher, Rosemary ^{[23
]}

机构：

[1] CI IPOP RISECI IPOP Hlth Res Network, Portuguese Oncol Inst Porto, Res Ctr IPO Porto, IPO Porto Porto Comprehens Canc Ctr Raquel Seruca, Rua Dr Antonio Bernardino Almeida, P-4200072 Porto, Portugal

[2] CHU S Joao, Rua Dr Antonio Bernardino Almeida, Rua Dr, P-4200072 Porto, Portugal

[3] Univ Barcelona, Inst Invest Biomed August PiSunyer IDIBAPS 1, Dept Pathol, Clin Barcelona,Dept Basic Clin Practice, Barcelona, Spain

[4] Univ Porto FMUP, Univ Hosp Ctr Sao Joao CHUSJ, Sch Hlth ESS, Polytech Inst Porto P PORTO,Dept Pathol,Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[5] Osped Maggiore AUSL Bologna, Anat Patolog, Bologna, Italy

[6] Geneva Univ Hosp, Div Clin Pathol, Geneva, Switzerland

[7] Univ Hosp Leuven, Dept Pathol, Louvain, Belgium

[8] Cork Univ Hosp, Dept Pathol, Cork, Ireland

[9] Univ Coll Cork, Cork Univ Hosp, Dept Clin Biochem, Dept Obstet & Gynaecol,Ireland Pregnancy Loss Res, Cork, Ireland

[10] Ctr Hospitalier Lyon Sud, Dept Pathol, Hosp Civils Lyon, Pierre Ben, France

[11] Imperial Coll Hosp NHS Trust, Charing Cross Hosp, Trophoblast Tumour Screening & Treatment Ctr, Fulham Palace Rd, London W6 8RF, England

[12] Oslo Univ Hosp, INNPATH Tirolkliniken, Dept Pathol, Innsbruck, Austria

[13] Cayenne Hosp Ctr Andree Rosemon, Dept Pathol, F-97306 Cayenne, France

[14] Cayenne Hosp Ctr Andree Rosemon, Ctr Biol Resources CRB Amazonie, F-97306 Cayenne, France

[15] Ghent Univ Hosp, Dept Pathol, Ghent, Belgium

[16] Ninewells Hosp, Med Sch, Scottish Hydatidiform Mole Follow Up Serv, Dundee, Scotland

[17] Aarhus Univ, Aalborg Univ Hosp, Dept Clin Genet, Denmark Dept Biomed, Aarhus, Denmark

[18] Inst Mother & Child Hlth, Dept Pathol, Warsaw, Poland

[19] Natl Matern Hosp, Dept Pathol, Dublin D02YH21, Ireland

[20] Karolinska Univ Hosp, Dept Pathol & Canc Diagnost, Stockholm, Sweden

[21] Rouen Univ Hosp, Dept Pathol, Rouen, France

[22] Imperial Coll NHS Trust, Dept Pathol, North West London Pathol, Fulham Palace Rd, London W6 8RF, England

[23] Imperial Coll London, Charing Cross Hosp, Dept Surg & Canc, Fulham Palace Rd, London W6 8RF, England

来源：

VIRCHOWS ARCHIV | 2024年 / 484卷 / 03期

关键词：

Hydatidiform moles; Pathology; Diagnosis; Genetics; Genotyping; Guidelines; IN-SITU-HYBRIDIZATION; GESTATIONAL TROPHOBLASTIC DISEASE; ANDROGENETIC/BIPARENTAL MOSAIC/CHIMERIC CONCEPTIONS; DISCORDANT P57 EXPRESSION; ANCILLARY-TECHNIQUES; TRIMESTER PLACENTAS; MOLAR COMPONENT; EARLY-PREGNANCY; DNA-PLOIDY; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/s00428-023-03658-8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts' group involved in its development.

引用

页码：401 / 422

页数：22

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