75 Years of Vitamin A Production: A Historical and Scientific Overview of the Development of New Methodologies in Chemistry, Formulation, and Biotechnology

被引：15

作者：

Bonrath, Werner ^{[1
]}

Gao, Bo ^{[2
]}

Houston, Peter ^{[3
]}

McClymont, Tom ^{[1
]}

Mu''ller, Marc-Andreï ^{[1
]}

Scha''fer, Christian ^{[1
]}

Schweiggert, Christiane ^{[1
]}

Schu''tz, Jan ^{[1
]}

Medlock, Jonathan A. ^{[1
]}

机构：

[1] DSM Firmenich, CH-4303 Kaiseraugst, Switzerland

[2] DSM Firmenich, Shanghai 201203, Peoples R China

[3] DSM Firmenich, Lexington, MA 02421 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2023年 / 27卷 / 09期

关键词：

Vitamins; retinol; process chemistry; biotechnology; formulation; chemical history; catalysis; HIGHLY STEREOSELECTIVE SYNTHESIS; TRANS-RETINOIC ACID; EMULSIFYING PROPERTIES; ALPHA; BETA-UNSATURATED ALDEHYDES; SOLUBLE POLYSACCHARIDE; ACTIVE INGREDIENTS; SULFONES; STABILITY; DELIVERY; OIL;

D O I：

10.1021/acs.oprd.3c00161

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In 1948, the firstkilograms of synthetic vitamin A (acetate) wereproduced by F. Hoffmann-La Roche, eliminating the need to extractthis vital compound from natural sources; this year marks 75 yearsof successful production. Since then, a number of chemical routeshave been commercialized. Of these, three processes have stood thetest of time and are still in use today, with only minor modifications.This review covers both the historical and scientific developmentsin the production of vitamin A derivatives from their beginnings upuntil recent developments including a fully catalytic process andthe successful pilot-scale production via fermentation. In addition,the development of formulation technologies, which have gone hand-in-handwith chemical process development, is described; correct formulationis essential for stabilizing vitamin A derivatives which are sensitiveto light and oxidation.

引用

页码：1557 / 1584

页数：28

共 217 条

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