Ginsenosides and Ginseng Phenolic Acids Relieve Ionizing Radiation-Induced Pyroptosis and Apoptosis in Intestinal Epithelial Cells

被引:1
作者
Shi, Kai [1 ,2 ,3 ]
Chen, Fei [1 ,2 ,3 ]
Li, Xiang [1 ,2 ,3 ]
Liang, Chen [1 ,2 ,3 ]
Sun, Haiming [4 ]
Yang, Tao [1 ,2 ,3 ]
Zheng, Junnian [2 ,3 ]
Ma, Bo [1 ,2 ,3 ,5 ]
Wei, Liang [1 ,2 ,3 ,5 ]
机构
[1] Xuzhou Med Univ, Canc Inst, 209Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Affiliated Hosp, Ctr Clin Oncol, Xuzhou, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Jiangsu Ctr Collaborat & Innovat Canc Biotherapy, Xuzhou, Jiangsu, Peoples R China
[4] Beihua Univ, Tradit Chinese Med Biotechnol Innovat Ctr Jilin Pr, Sch Pharm, Jilin, Peoples R China
[5] Xuzhou Med Univ, Canc Inst, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
关键词
steroids; phenolics; ginsenosides; ginseng phenolic acids; radiation; pyroptosis; apoptosis; CANCER-CELLS; EXTRACT; RD; ANTIOXIDANT; PATHWAYS; DAMAGE; BCL-2; MEYER; MICE;
D O I
10.1177/1934578X231189954
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Exposure to ionizing radiation (IR) during procedures such as abdominal and pelvic radiotherapy results in severe intestinal injury. In the current study, we demonstrated that a lethal dose of IR triggered intestinal epithelial cell apoptosis and pyroptosis via Caspase-3 cleavage. The ginseng active ingredients, ginsenosides (GS) and ginseng phenolic acids (GPA), significantly inhibited IR-induced apoptosis in IEC-6 cells. GS and GPA also reduced Caspase-3 and GSDME cleavage and HMGB1 and LDH release, thus inhibiting pyroptosis after IR. Moreover, GS- or GPA-treated IEC-6 cells showed reduced reactive oxygen species and DNA damage accumulation. These results suggest that IR induces apoptosis and GSDME-dependent pyroptosis through Caspase-3 activation, which can be relieved by GS and GPA, thus supporting the potential use of GS and GPA in the prevention and treatment of IR-induced intestinal injury.
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页数:14
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共 48 条
[41]   Atorvastatin Attenuates Radiotherapy-Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects [J].
Wei, Ming-Feng ;
Cheng, Ching-Hsueh ;
Wen, Shu-Yu ;
Lin, Jui-Chueh ;
Chen, Yu-Hsuan ;
Wang, Chun-Wei ;
Lee, Yi-Hsuan ;
Kuo, Sung-Hsin .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
[42]   Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy [J].
Xiao, Yao ;
Zhang, Tian ;
Ma, Xianbin ;
Yang, Qi-Chao ;
Yang, Lei-Lei ;
Yang, Shao-Chen ;
Liang, Mengyun ;
Xu, Zhigang ;
Sun, Zhi-Jun .
ADVANCED SCIENCE, 2021, 8 (24)
[43]   Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice [J].
Yokozawa, T ;
Satoh, A ;
Cho, EJ .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2004, 56 (01) :107-113
[44]   Role of ginsenoside-Rd in cisplatin-induced renal injury: Special reference to DNA fragmentation [J].
Yokozawa, T ;
Dong, E .
NEPHRON, 2001, 89 (04) :433-438
[45]   Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells [J].
Yu, Junhui ;
Li, Shan ;
Qi, Jie ;
Chen, Zilu ;
Wu, Yunhua ;
Guo, Jing ;
Wang, Kai ;
Sun, Xuejun ;
Zheng, Jianbao .
CELL DEATH & DISEASE, 2019, 10 (3)
[46]   Small molecules regulating reactive oxygen species homeostasis for cancer therapy [J].
Zhang, Junmin ;
Duan, Dongzhu ;
Song, Zi-Long ;
Liu, Tianyu ;
Hou, Yanan ;
Fang, Jianguo .
MEDICINAL RESEARCH REVIEWS, 2021, 41 (01) :342-394
[47]   Gasdermin E suppresses tumour growth by activating anti-tumour immunity [J].
Zhang, Zhibin ;
Zhang, Ying ;
Xia, Shiyu ;
Kong, Qing ;
Li, Shunying ;
Liu, Xing ;
Junqueira, Caroline ;
Meza-Sosa, Karla F. ;
Mok, Temy Mo Yin ;
Ansara, James ;
Sengupta, Satyaki ;
Yao, Yandan ;
Wu, Hao ;
Lieberman, Judy .
NATURE, 2020, 579 (7799) :415-+
[48]   Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis [J].
Zhou, Bo ;
Zhang, Jia-yuan ;
Liu, Xian-shuo ;
Chen, Hang-zi ;
Ai, Yuan-li ;
Cheng, Kang ;
Sun, Ru-yue ;
Zhou, Dawang ;
Han, Jiahuai ;
Wu, Qiao .
CELL RESEARCH, 2018, 28 (12) :1171-1185