The Role of the Microbiome in First Episode of Psychosis

被引：9

作者：

Nuncio-Mora, Lucero ^{[1
,2
]}

Lanzagorta, Nuria ^{[3
]}

Nicolini, Humberto ^{[1
,3
]}

Sarmiento, Emmanuel ^{[4
]}

Ortiz, Galo ^{[4
]}

Sosa, Fernanda ^{[3
,4
]}

Genis-Mendoza, Alma Delia ^{[1
,4
]}

机构：

[1] Natl Inst Genom Med, Lab Genom Psychiat & Neurodegenerat Dis, Mexico City 14610, Mexico

[2] Posgrad Unit, Posgrad Studies Biol Sci, Posgrad Circuit,Univ City,Bldg,1st Floor, Mexico City 04510, Mexico

[3] Carraci Med Grp, Mexico City 03740, Mexico

[4] Psychiat Childrens Hosp Dr Juan N Navarro, Mexico City 14080, Mexico

来源：

BIOMEDICINES | 2023年 / 11卷 / 06期

关键词：

microbiome; dysbiosis; first episode of psychosis; brain-gut-microbiome axis; GUT MICROBIOME; SCHIZOPHRENIA; EVOLUTION; BEHAVIOR; TRANSPLANT; ACTIVATION; BACTERIA; DEFICITS; CELLS;

D O I：

10.3390/biomedicines11061770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera Lactobacillus and Megasphaera are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed.

引用

页数：15

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