HPLC DETERMINATION OF BIPERIDEN IN SOLID DOSAGE FORMS

被引：0

作者：

Angelov, Trifon Milchev ^{[1
]}

Krastanova, Biljana Slaveva ^{[2
]}

Pashev, Alexandar Svilenov ^{[1
]}

Jotova, Maya Chavdarova ^{[1
]}

机构：

[1] Med Univ Pleven, Fac Pharm, 1 St Kliment Ohridski St, Pleven 5800, Bulgaria

[2] Tchaikapharma High Qual Med Inc, 1 GM Dimitrov Blvd, Sofia 1172, Bulgaria

来源：

COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2023年 / 76卷 / 02期

关键词：

biperiden; HPLC-UV; assay; method development;

D O I：

10.7546/CRABS.2023.02.02

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A rapid, new analytical method, based on liquid chromatography with UV detection, has been developed and utilised for the determination of biperi-den hydrochloride in solid dosage forms. The chromatographic separation was performed on a conventional C18 reversed phase column with a mobile phase composed of acetonitrile-buffer mixture. Ultraviolet detection was carried out at 205 nm. A rapid extraction procedure using ultrasonic bath obtained good extraction yield values for the analyte (>= 98.4%). The method was developed specifically for routine analysis of biperiden in solid dosage forms in the appli-cable concentration range. The linearity and range of the method investigated for the assay of biperiden is between 2-6 mu g mL-1. The method is selective and sufficiently precise. Thus, the method developed is suitable for routine analysis of biperiden.

引用

页码：184 / 191

页数：8

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