Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

被引：12

作者：

Adamo, Daniela ^{[1
]}

Calabria, Elena ^{[1
]}

Canfora, Federica ^{[1
]}

Coppola, Noemi ^{[1
]}

Leuci, Stefania ^{[1
]}

Mignogna, Martina ^{[1
]}

Muzio, Lorenzo Lo ^{[2
]}

Spirito, Francesca ^{[2
]}

Giuliani, Michele ^{[2
]}

Azzi, Lorenzo ^{[3
]}

Dani, Marta ^{[3
]}

Colella, Giuseppe ^{[4
]}

Colella, Chiara ^{[4
]}

Montebugnoli, Lucio ^{[5
]}

Gissi, Davide Bartolomeo ^{[5
]}

Gabriele, Mario ^{[6
]}

Nisi, Marco ^{[6
]}

Sardella, Andrea ^{[7
]}

Lodi, Giovanni ^{[7
]}

Varoni, Elena Maria ^{[7
]}

Giudice, Amerigo ^{[8
]}

Antonelli, Alessandro ^{[8
]}

Gambino, Alessio ^{[9
]}

Antonucci, Giuliana ^{[9
,12
]}

Vescovi, Paolo ^{[10
,12
]}

Meleti, Marco ^{[10
]}

Majorana, Alessandra ^{[11
]}

Bardellini, Elena ^{[11
]}

Campisi, Giuseppina ^{[12
]}

Panzarella, Vera ^{[12
]}

Spadari, Francesco ^{[13
]}

Garagiola, Umberto ^{[13
]}

Pentenero, Monica ^{[14
]}

Sutera, Samuele ^{[14
]}

Biasotto, Matteo ^{[15
]}

Ottaviani, Giulia ^{[15
]}

Gobbo, Margherita ^{[15
,16
]}

Nardini, Luca Guarda ^{[16
]}

Romeo, Umberto ^{[17
]}

Tenore, Gianluca ^{[17
]}

Serpico, Rosario ^{[4
]}

Lucchese, Alberta ^{[4
]}

Lajolo, Carlo ^{[18
]}

Gioco, Gioele ^{[18
]}

Aria, Massimo ^{[19
]}

D'Aniello, Luca ^{[20
]}

Mignogna, Michele Davide ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod Sci & Dent, Naples, Italy

[2] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[3] Univ Insubria, ASST Sette Laghi, Dept Med & Surg, Unit Oral Med & Pathol, Varese, Italy

[4] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Dent Specialties, Naples, Italy

[5] Univ Bologna, Dept Biomed & Neuromotor Sci, Sect Oral Sci, Bologna, Italy

[6] Univ Pisa, Dept Surg Pathol Med Mol & Crit Area, Pisa, Italy

[7] Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

[8] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[9] Univ Turin, CIR Dent Sch, Dept Surg Sci, Oral Med Sect, Turin, Italy

[10] Univ Parma, Univ Ctr Dent, Dept Med & Surg, Oral Med & Laser Surg Unit, Parma, Italy

[11] Univ Brescia, Dept Med & Surg Special, Radiol Sci & Publ Hlth, Brescia, Italy

[12] Univ Palermo, Dept Surg Oncol & Oral Sci, Palermo, Italy

[13] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Biomed Surg & Dent Sci, Maxillo Facial & Dent Unit, Milan, Italy

[14] Univ Turin, Dept Oncol, Oral Med & Oral Oncol Unit, Turin, Italy

[15] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[16] Ca Foncello Hosp, Unit Oral & Maxillofacial Surg, Treviso, Italy

[17] Univ Roma La Sapienza, Dept Oral Sci & Maxillofacial Surg, Rome, Italy

[18] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Sch Dent, Head & Neck Dept, Rome, Italy

[19] Univ Federico II Naples, Dept Econ & Stat, Naples, Italy

[20] Univ Federico II Naples, Dept Social Sci, Naples, Italy

来源：

CLINICAL ORAL INVESTIGATIONS | 2023年 / 27卷 / 06期

关键词：

Keratotic oral lichen planus; Depression; Anxiety; Mood disorder; Pain; RATING-SCALE; DISORDERS; DYSBIOSIS; DISEASE; PAIN;

D O I：

10.1007/s00784-023-04909-3

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectivesOral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status.MethodsThree hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered.ResultsThe K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001*). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**).ConclusionsThe prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood.

引用

页码：3057 / 3069

页数：13

共 47 条

[21] Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus [J].