Multi-omics data integration methods and their applications in psychiatric disorders

被引：40

作者：

Sathyanarayanan, Anita ^{[1
]}

Mueller, Tamara T. ^{[2
]}

Moni, Mohammad Ali ^{[3
]}

Schueler, Katja ^{[4
,5
]}

Baune, Bernhard T. ^{[6
,7
,8
]}

Lio, Pietro ^{[9
]}

Mehta, Divya ^{[1
]}

机构：

[1] Queensland Univ Technol, Fac Hlth, Ctr Genom & Personalised Hlth, Sch Biomed Sci, Kelvin Grove, Qld 4059, Australia

[2] Tech Univ Munich, Inst Artificial Intelligence & Informat Med, D-80333 Munich, Germany

[3] Univ Queensland, Fac Hlth & Behav Sci, Sch Hlth & Rehabil Sci, Artificial Intelligence & Digital Hlth Data Sci, St Lucia, Qld 4072, Australia

[4] Hosp Zum Heiligen Geist, Clin Psychosomat, Frankfurt, Germany

[5] Frankfurt Psychoanalyt Inst, Frankfurt, Germany

[6] Univ Munster, Dept Psychiat & Psychotherapy, Munster, Germany

[7] Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Melbourne, Vic, Australia

[8] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[9] Univ Cambridge, Dept Comp Sci & Technol, Cambridge, England

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2023年 / 69卷

关键词：

Multi-omics; Genomics; Transcriptomics; Statistics; Machine learning; Psychiatry; Bench to bedside; GENOME-WIDE ASSOCIATION; SUPPORT-SYSTEM; MENTAL-HEALTH; TRANSCRIPTOME; BRAIN; SCHIZOPHRENIA; METHYLATION; DEPRESSION; ENRICHMENT; CHALLENGES;

D O I：

10.1016/j.euroneuro.2023.01.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

combine the information rich multi-omics data to discover biologically meaningful biomarkers for diagnosis, treatment, and prognosis. However, clinical translation of the research is still challenging. In this review, we summarise conventional and state-of-the-art statistical and ma-chine learning approaches for discovery of biomarker, diagnosis, as well as outcome and treat-ment response prediction through integrating multi-omics and clinical data. In addition, we describe the role of biological model systems and in silico multi-omics model designs in clinical translation of psychiatric research from bench to bedside. Finally, we discuss the current chal-lenges and explore the application of multi-omics integration in future psychiatric research. The review provides a structured overview and latest updates in the field of multi-omics in psychiatry. (c) 2023 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：26 / 46

页数：21

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