The Role of NLRP3 Inflammasome in IgA Nephropathy

被引：7
作者：
Wu, Xiaofang [1 ]
Zhao, Lei [1 ]
Li, Kailong [1 ]
Yang, Jurong [1 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 3, Dept Nephrol, Chongqing 400120, Peoples R China
来源：
MEDICINA-LITHUANIA | 2023年 / 59卷 / 01期
关键词：
autophagy; exosomes; IgA nephropathy; NF-kappa B; NLRP3; inflammasome; ROS; ACUTE KIDNEY INJURY; ISCHEMIA/REPERFUSION INJURY; ACTIVATION; AUTOPHAGY; EXOSOMES; INHIBITION; MECHANISMS; STRESS; CELLS; TXNIP;
D O I：
10.3390/medicina59010082
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. This review focuses on the role of the NLRP3 inflammasome in IgAN and summarizes multiple involved pathways, which may provide novel treatments for IgAN treatment.
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页数：8
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