SARS-CoV-2 infection and vaccination in patients with hairy-cell leukaemia

被引：4

作者：

Tiacci, Enrico ^{[1
,2
]}

Mancini, Alessandro ^{[1
,2
]}

Marchetti, Monia ^{[3
]}

D'Elia, Gianna Maria ^{[4
]}

Candoni, Anna ^{[5
]}

Morotti, Alessandro ^{[6
]}

Romano, Alessandra ^{[7
]}

Gozzetti, Alessandro ^{[8
]}

Broccoli, Alessandro ^{[9
,10
]}

De Carolis, Luca ^{[1
,2
]}

Bruna, Riccardo ^{[11
]}

Tisi, Maria Chiara ^{[12
]}

Selleri, Carmine ^{[13
]}

Capponi, Monia ^{[1
,2
]}

Vallisa, Daniele ^{[14
]}

Cattaneo, Chiara ^{[15
]}

Della Porta, Matteo Giovanni ^{[16
]}

Busca, Alessandro ^{[17
]}

Falini, Brunangelo ^{[1
,2
]}

Massaia, Massimo ^{[18
]}

Bertu, Lorenza ^{[19
]}

Pulsoni, Alessandro ^{[4
]}

Rivela, Paolo ^{[3
]}

Corradini, Paolo

Passamonti, Francesco

机构：

[1] Univ & Osped Perugia, Ist Ematol, Dipartimento Med & Chirurg, Perugia, Italy

[2] Univ & Osped Perugia, Ctr Ric Emato Oncolog, Perugia, Italy

[3] Azienda Ospedaliera Ss Antonio & Biagio & Cesare, Hematol Unit, Alessandria, Italy

[4] Osped Umberto I, Ematol, Rome, Italy

[5] Azienda Sanit Univ Friuli Cent ASUFC, Clin Ematolog, Udine, Italy

[6] Univ Torino, Dipartimento Sci Clin & Biol, Turin, Italy

[7] Osped Catania, Ematol, Catania, Italy

[8] Osped Siena, Ematol, Siena, Italy

[9] Univ Bologna, Ist Ematol Seragnoli, IRCCS Azienda Ospedaliero, Bologna, Italy

[10] Univ Bologna, Dipartimento Med Specialist Diagnost & Sperimenta, Div Ematol, Bologna, Italy

[11] Osped Novara, Ematol, Novara, Italy

[12] San Bortolo Hosp, Cell Therapy & Hematol, Vicenza, Italy

[13] Osped Salerno, Ematol, Salerno, Italy

[14] Osped Piacenza, Ematol, Piacenza, Italy

[15] ASST Spedali Civili Brescia, Ematologia, Brescia, Italy

[16] Humanitas Univ, IRCCS Humanitas Clin & Res Ctr, Dept Biomed Sci, Milan, Italy

[17] AOU Citta Salute & Sci, SSD Trapianto Cellule Staminali, Turin, Italy

[18] Univ Torino, Cuneo Mol Biotechnol Ctr G Tarone, SC Ematol, AO S Croce & Carle, Turin, Italy

[19] Univ Insubria, Dipartimento Med & Chirurg, Varese, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 201卷 / 03期

关键词：

anti-SARS-CoV-2; vaccination; COVID-19; hairy-cell leukaemia; post-COVID-19; seroconversion; COVID-19; ANTIBODY;

D O I：

10.1111/bjh.18606

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Little is known of the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti-leukaemic treatment, developed COVID-19 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (n = 11 cases) and postvaccination (n = 28) seroconversion consistently developed, except after recent anti-CD20 or venetoclax therapy, correlating with perivaccine B-cell count. Vaccination appeared to protect from severe COVID-19 in 11 patients with breakthrough infection.

引用

页码：411 / 416

页数：6

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